{"id":390,"date":"2022-02-23T13:39:05","date_gmt":"2022-02-23T19:39:05","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/cio\/?page_id=390"},"modified":"2026-10-13T13:25:14","modified_gmt":"2026-10-13T18:25:14","slug":"home","status":"publish","type":"page","link":"https:\/\/wp.uthscsa.edu\/cio\/","title":{"rendered":"Home"},"content":{"rendered":"

[vc_row][vc_column][vc_column_text]<\/p>\n

Welcome to the Center for Inherited Oncogenesis!<\/h2>\n

[\/vc_column_text][\/vc_column][\/vc_row][vc_row el_class=”margin-bottom”][vc_column][vc_row_inner][vc_column_inner width=”1\/3″] \n \n \n <\/i>\n <\/i>\n <\/span>

Research<\/h3>\n <\/a>[\/vc_column_inner][vc_column_inner width=”1\/3″] \n \n \n <\/i>\n <\/i>\n <\/span>

Seminars<\/h3>\n <\/a>[\/vc_column_inner][vc_column_inner width=”1\/3″] \n \n \n <\/i>\n <\/i>\n <\/span>

Publications<\/h3>\n <\/a>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row full_width=”stretch_row” content_placement=”middle” equal_height=”yes” el_class=”bleed color grey roomy”][vc_column width=”1\/3″][vc_single_image onclick=”custom_link” image=”526″ img_size=”medium” alignment=”center” link=”https:\/\/directory.uthscsa.edu\/academics\/profile\/gayther”][\/vc_column][vc_column width=”2\/3″][vc_column_text]<\/p>\n

Welcome from the Director<\/h2>\n
\n

Here at the Center for Inherited Oncogenesis, our goal is to find common <\/span>low risk<\/span> and rare <\/span>high risk<\/span> germline genetic variation in the South Texas population that contribute to an increase in cancer risk and to understand the functional role or genetic risk factors in the pathogenesis of cancer. We want to <\/span>identify<\/span> genetic variants like <\/span><\/span>BRCA1 <\/span><\/span>and <\/span><\/span>BRCA2 <\/span><\/span>mutations and evaluate their contribution to a cancer predisposition. We use spatial <\/span>multiomics<\/span> profiling and integrated \u2018big data\u2019 analyses to see how genetic variation affects cancer pathogenesis at the cell-type specific level. And we use functional tools, including induced pluripotent stem cell (iPSC) modeling and CRISPR\/Cas9 screening to study the function of genetic risk factors in cancer initiation and development. Along the way, we hope to teach and train undergraduates, graduates, MD and PhD students, postdoctoral <\/span>scientists<\/span> and faculty at all stages of their careers about germline genetics and cancer predisposition to improve the prevention of disease, whether it be <\/span>identifying<\/span> new screening and diagnostic biomarkers or novel drugs targets for prevention and treatment. <\/span><\/span><\/p>\n

Simon Gayther, PhD<\/span><\/b><\/a>
\n<\/span>Professor, Med\/Hematology & Med Oncology<\/span>
\n<\/span>Director, Center for Inherited Oncogenesis
\n<\/span>Co-Director, Population Science and Prevention Program<\/div>\n

[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_column_text] Welcome to the Center for Inherited Oncogenesis! 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