{"id":1458,"date":"2025-12-03T08:57:41","date_gmt":"2025-12-03T14:57:41","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/cpm\/?page_id=1458"},"modified":"2025-12-03T09:02:57","modified_gmt":"2025-12-03T15:02:57","slug":"center-for-precision-medicine-cpm","status":"publish","type":"page","link":"https:\/\/wp.uthscsa.edu\/cpm\/center-for-precision-medicine-cpm\/","title":{"rendered":"Center for Precision Medicine (CPM)"},"content":{"rendered":"<div class=\"wpb-content-wrapper\" id=\"wpb-content-root\"><p>[vc_row][vc_column]\n            <div class=\"callout outline  \" >\n                    <\/p>\n<h3><em>From bench to bedside: Translating new discoveries for complex diseases<\/em><\/h3>\n<p>\n<\/div>[vc_column_text css=&#8221;&#8221;]The Center for Precision Medicine (CPM) drives breakthroughs that transform patient care. By integrating biomarkers, imaging, spatial omics and advanced analytics with clinical research, CPM enables investigators to cross the \u201cvalley of death\u201d between discovery and the clinic\u2014to bridge the gap between discovery and clinical application\u2014and ensure the right patient receives the right therapy at the right time.[\/vc_column_text][\/vc_column][\/vc_row][vc_row equal_height=&#8221;yes&#8221;][vc_column width=&#8221;1\/2&#8243;]\n            <div class=\"callout  \" >\n                    <h2 class=\"h4\">Why this matters now<\/h2><\/p>\n<ul>\n<li>Complex diseases often go untreated<\/li>\n<li>Treatments will require a molecular diagnosis for individual patients<\/li>\n<li>Cardiovascular disease, neurodegenerative disease liver, lung and kidney affect 90% of US population with high mortality and poor quality of life<\/li>\n<li>New omics tools and big data analysis are available for clinical biopsies and clinical samples<\/li>\n<li>Cancer: In 2025, an estimated 2,041,910 Americans will be diagnosed with cancer and 618,120 will die from it; roughly 38.9% of men and women will be diagnosed at some point in their lifetimes.<\/li>\n<li>Neurodegenerative disease (Alzheimer\u2019s): About 7.2 million Americans (65+) are living with Alzheimer\u2019s in 2025, and the total is projected to reach ~14 million by 2060.<\/li>\n<li>Cardiovascular disease: The nation\u2019s leading killer\u2014someone dies about every 34 seconds, and ~805,000 Americans have a heart attack each year.<\/li>\n<li>Kidney disease: More than 1 in 7 U.S. adults (~35.5M) live with chronic kidney disease and ~360 people begin dialysis every day.<\/li>\n<\/ul>\n<p>\n<\/div>[\/vc_column][vc_column width=&#8221;1\/2&#8243;]\n            <div class=\"callout  \" >\n                    <h2 class=\"h4\">CPM Unique Capabilities<\/h2><p>\u2022 Integrate spatial omics, imaging and AI with clinical phenotyping to pinpoint disease drivers.<br \/>\n\u2022 Move rapidly from hypothesis to human relevance via patient\u2011centered biobanks and clinical trials.<br \/>\n\u2022 Build local, regional and national partnerships, including the Center for Innovative Drug Discovery (CiDD), Institute for Integration of Medicine and Science (IIMS), Center for Brain Health, the Glenn Biggs Institute for Alzheimer\u2019s and Neurodegenerative Diseases, Southwest Research Institute (SwRI\u00ae), Texas Biomed, and Mays Cancer Center, to scale discoveries into therapies.<\/p>\n<\/div>[\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1764773556813{margin-top: 35px !important;}&#8221;]<\/p>\n<h4>Leadership and Platform<\/h4>\n<ul>\n<li><strong> Director, CPM: <\/strong>Kumar Sharma, MD \u2014 Professor, Chief of Nephrology and Vice Chair for Research.<\/li>\n<li><strong>Co\u2011Director, CPM: <\/strong>James D. Lechleiter, PhD \u2014 Professor of Cell Systems and Anatomy; prior Director, Optical Imaging Core, current co-Leader, Optical Imaging Shared Resource<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_single_image image=&#8221;1469&#8243; alignment=&#8221;center&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<ul>\n<li><strong>Strategic partners<\/strong>: Center for Innovative Drug Discovery (CiDD), Institute for the Integration of Medicine and Science (IIMS), University of Texas at San Antonio (UT San Antonio), Southwest Research Institute (SwRI\u00ae), Texas Biomed<\/li>\n<li><strong>Unique capabilities<\/strong>: biomarker discovery\/validation, spatial metabolomics, spatial transcriptomics, spatial proteomics, advanced imaging, patient\u2011centered bioinformatics, clinical trial integration, organoid screening<\/li>\n<\/ul>\n<h5>Key members for biomedical\/AI expertise and clinical applications<\/h5>\n<p><strong>Biomedical\/AI expertise:<\/strong> Daohong Zhao, MD; Guanshi Zhang, PhD; Yaxia Yang, PhD (therapeutics); Kal Clark, MD (radiology and AI); Kate Lawrenson, PhD (spatial transcriptomics, bioinformatics); Simon Gayther, PhD (genomics); Mark Goldberg, MD, PhD (stroke, axonal injury); Amina Qutub, PhD (AI and lymphatics); Agustin Ruiz, PhD (AD multi-omics); Jingyong Ye. PhD (diagnostics, sensors); Aleksandra Gruslova. PhD (vascular calcification); Meredith Zozus, PhD (medical informatics); and Jonathan Gelfond MD, PhD (biostatistics)<\/p>\n<p><strong>Clinicians<\/strong>: Carlayne Jackson, MD (ALS); Allen Anderson, MD (heart failure); Marc Feldman, MD (interventional cardiovascular); Anoop Nambiar, MD (pulmonary); Matt Butler, MD (oncology); Anand Karnad, MD (Hematology); Swetha Kanduri, MD (onco-nephrology and rare diseases); Tareq Nassar, MD (glomerulonephritis); Wajeh Qunibi, MD (vascular calcification); Sarah Lapey, MD (liver disease); Prabhleen Chahal, MD (advanced intervention); Sarwat Gilani, MD; Ram Akilesh, MD (University of Washington); \u00a0and Jeff Hodgin, MD, Pathology (University of Michigan)<\/p>\n<h5>Featured clinical and translational projects<\/h5>\n<ul>\n<li>BRISK: Bupropion for Fatigue in End\u2011stage Kidney Disease Patients on Hemodialysis \u2014 pilot interventional trial; CPM measures active metabolites. <em><em>(ClinicalTrials.gov NCT06609343)<\/em><\/em><\/li>\n<li>OASIS: Oral intradialytic essential amino acids to reduce fatigue, frailty and cognitive burden in dialysis \u2014 CPM targeted metabolomics in plasma. <em><em>(ClinicalTrials.gov NCT05705414)<\/em><\/em><\/li>\n<li>Spatial metabolomics in rare renal disease (Dense Deposit Disease) and metabolomics in renal biopsies \u2014 defining molecular drivers to inform therapy.<\/li>\n<li>Post\u2011hoc precision analysis of SGLT2\/SGLT1\u20112 inhibitors on urine adenine levels \u2014 linking mechanism to patient\u2011level biomarker change.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h5>Your gift accelerates impact and helps bridge the \u201cvalley of death\u201d<\/h5>\n<p>[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=&#8221;.vc_custom_1764715770935{background-color: #A7A7A7 !important;}&#8221;][vc_column][vc_row_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"234\">\n<h5>Discovery<\/h5>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"234\">Equip spatial omics &amp; imaging<br \/>\n(instruments, assays, data)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"234\">\n<h5>Translation<\/h5>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"234\">Seed high\u2011potential pilots<br \/>\n(biomarkers, target validation)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_column_text css=&#8221;&#8221;]<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"234\">\n<h5>Clinical Impact<\/h5>\n<\/td>\n<\/tr>\n<tr>\n<td width=\"234\">Launch patient\u2011focused studies<br \/>\n(trials, biobanks, outreach)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text css=&#8221;&#8221;]<\/p>\n<h5>Philanthropic priorities and recognition<\/h5>\n<ul>\n<li><strong> Equip the platform with state-of-the-art technology: <\/strong>Mass spectrometry imaging as instrument improves every 2-3 years, advanced optical imaging, and assay development.<\/li>\n<li><strong> Accelerate projects: <\/strong>Pilot grants that bridge discovery to first\u2011in\u2011human readiness; matching\u2011gift challenges.<\/li>\n<li><strong> Power clinical studies: <\/strong>Interventional trials in neurologic diseases, rare cancers, cardiovascular diseases, and rare kidney and liver disease.<\/li>\n<li><strong> Train talent: <\/strong>Named student\/fellowships in AI, precision medicine and data science; visiting scholar lectureships.<\/li>\n<li><strong> Advance equity: <\/strong>Expand diverse biobanks and community partnerships across South Texas.<\/li>\n<\/ul>\n<p><strong>Recognition options include <\/strong>Named funds, endowed fellowships, lecture series sponsorships, equipment naming, and symposium support.<\/p>\n<h5>Momentum<\/h5>\n<p>[\/vc_column_text][vc_row_inner][vc_column_inner css=&#8221;.vc_custom_1764773778323{margin-top: -20px !important;}&#8221;]\n            <div class=\"callout beige \" >\n                    <h5 class=\"h5\">Recent publications highlighting advances in Precision Medicine<\/h5><\/p>\n<ul>\n<li><em>Nature Reviews Nephrology,<\/em> 2025: CPM\u2019s manuscript on spatial metabolomics &amp; multi\u2011omics for kidney precision medicine.<\/li>\n<li><em>American Journal of Physiology,<\/em> 2025: New treatment for acute kidney injury and precision diagnostics<\/li>\n<li><em>Nature Reviews Nephrology<\/em>, 2024: New technologies for precision medicine<\/li>\n<li><em>Journal of Clinical Investigation Insight<\/em> 2024: New therapeutic target for neuroinflammation following kidney injury<\/li>\n<li><em>Journal of Clinical Investigation, <\/em>2023 New therapeutic and biomarker for kidney failure with diabetes<\/li>\n<\/ul>\n<p><strong><em>Additionally: <\/em><\/strong><em>First Annual Symposium on Spatial Omics and Artificial Intelligence<strong>,<\/strong><\/em> held at UT Health San Antonio, September 2025. Enthusiastic, record audience, hosted by the Center for Precision Medicine.<\/p>\n<\/div>[vc_column_text css=&#8221;&#8221;]Scan below to learn more about the Center for Precision Medicine at UT Health San Antonio as well as how you can support or collaborate with us.[\/vc_column_text][vc_single_image image=&#8221;1495&#8243; alignment=&#8221;center&#8221; style=&#8221;vc_box_border&#8221; css=&#8221;&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: center\">Center for Precision Medicine \u2022 UT Health San Antonio \u2022 7703 Floyd Curl Drive, San Antonio, TX 78229 \u2022 <a href=\"tel:+12105674700\">(210) 567\u20114700<\/a> \u2022 <a href=\"mailto:cpm@uthscsa.edu\">cpm@uthscsa.edu<\/a><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]The Center for Precision Medicine (CPM) drives breakthroughs that transform patient care. By integrating biomarkers, imaging, spatial omics and advanced analytics with clinical research, CPM enables investigators to cross the \u201cvalley of death\u201d between discovery and the clinic\u2014to bridge the gap between discovery and clinical application\u2014and ensure the right patient receives the right therapy [&hellip;]<\/p>\n","protected":false},"author":320,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1458","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Center for Precision Medicine (CPM) - Center for Precision Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wp.uthscsa.edu\/cpm\/center-for-precision-medicine-cpm\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Center for Precision Medicine (CPM) - Center for Precision Medicine\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]The Center for Precision Medicine (CPM) drives breakthroughs that transform patient care. 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