{"id":455,"date":"2021-04-16T11:53:47","date_gmt":"2021-04-16T16:53:47","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/crpm\/?page_id=455"},"modified":"2023-10-25T09:01:49","modified_gmt":"2023-10-25T14:01:49","slug":"dr-kumar-sharma-featured-spotlight","status":"publish","type":"page","link":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/","title":{"rendered":"Dr. Kumar Sharma Featured Spotlight"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]<a href=\"https:\/\/directory.uthscsa.edu\/academics\/profile\/sharmak3\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-421 size-medium\" src=\"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133-285x400.jpg\" alt=\"\" width=\"285\" height=\"400\" srcset=\"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133-285x400.jpg 285w, https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133.jpg 321w\" sizes=\"auto, (max-width: 639px) 98vw, (max-width: 1199px) 64vw, 285px\" \/><\/a>Dr. Sharma is an internationally renowned expert in kidney disease whose research has focused primarily on the pathogenesis of diabetic kidney disease (DKD).<\/p>\n<p>He has consistently taken a translational approach to research, utilizing animal and cell culture models to further our understanding of disease, testing hypotheses in clinical studies, and pursuing promising therapeutics in clinical trials.<\/p>\n<p>His laboratory helped define the central role of the cytokine Transforming Growth Factor-b (TGF-b) in DKD and contributed to the development of a highly innovative anti-fibrotic approach that was tested in a clinical research trial under Dr. Sharma\u2019s guidance.<\/p>\n<p>His group was also the first to describe the role of adiponectin in podocyte function and has been a major contributor to our understanding of the role of AMPK in DKD.<\/p>\n<p>In 2013 Dr. Sharma\u2019s group published a paradigm-shifting paper on superoxides in DKD which highlighted the impact of altered cellular metabolism on the disease process.<\/p>\n<p>Recent studies with metabolomics have established a key role for mitochondrial dysfunction in DKD and have identified key metabolites whose levels are altered in DKD.<\/p>\n<p>These metabolites may serve as biomarkers for individuals at risk for developing DKD, and current clinical studies to pursue this hypothesis are underway under Dr. Sharma\u2019s leadership.<\/p>\n<p><a href=\"https:\/\/directory.uthscsa.edu\/academics\/profile\/sharmak3\">To learn more about Dr. Sharma, click here.<\/a>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/3&#8243;][vc_raw_html]JTNDaWZyYW1lJTIwd2lkdGglM0QlMjI1NjAlMjIlMjBoZWlnaHQlM0QlMjIzMTUlMjIlMjBzcmMlM0QlMjJodHRwcyUzQSUyRiUyRnd3dy55b3V0dWJlLmNvbSUyRmVtYmVkJTJGM3oxOVFjU1JVWE0lMjIlMjB0aXRsZSUzRCUyMllvdVR1YmUlMjB2aWRlbyUyMHBsYXllciUyMiUyMGZyYW1lYm9yZGVyJTNEJTIyMCUyMiUyMGFsbG93JTNEJTIyYWNjZWxlcm9tZXRlciUzQiUyMGF1dG9wbGF5JTNCJTIwY2xpcGJvYXJkLXdyaXRlJTNCJTIwZW5jcnlwdGVkLW1lZGlhJTNCJTIwZ3lyb3Njb3BlJTNCJTIwcGljdHVyZS1pbi1waWN0dXJlJTIyJTIwYWxsb3dmdWxsc2NyZWVuJTNFJTNDJTJGaWZyYW1lJTNF[\/vc_raw_html][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Dr. Sharma is an internationally renowned expert in kidney disease whose research has focused primarily on the pathogenesis of diabetic kidney disease (DKD). He has consistently taken a translational approach to research, utilizing animal and cell culture models to further our understanding of disease, testing hypotheses in clinical studies, and pursuing promising therapeutics in [&hellip;]<\/p>\n","protected":false},"author":326,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-455","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Dr. Kumar Sharma Featured Spotlight - Center for Precision Medicine<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dr. Kumar Sharma Featured Spotlight - Center for Precision Medicine\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Dr. Sharma is an internationally renowned expert in kidney disease whose research has focused primarily on the pathogenesis of diabetic kidney disease (DKD). He has consistently taken a translational approach to research, utilizing animal and cell culture models to further our understanding of disease, testing hypotheses in clinical studies, and pursuing promising therapeutics in [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/\" \/>\n<meta property=\"og:site_name\" content=\"Center for Precision Medicine\" \/>\n<meta property=\"article:modified_time\" content=\"2023-10-25T14:01:49+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133-285x400.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/\",\"url\":\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/\",\"name\":\"Dr. Kumar Sharma Featured Spotlight - Center for Precision Medicine\",\"isPartOf\":{\"@id\":\"https:\/\/wp.uthscsa.edu\/cpm\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133-285x400.jpg\",\"datePublished\":\"2021-04-16T16:53:47+00:00\",\"dateModified\":\"2023-10-25T14:01:49+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#primaryimage\",\"url\":\"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133.jpg\",\"contentUrl\":\"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133.jpg\",\"width\":321,\"height\":450},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/wp.uthscsa.edu\/cpm\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Dr. Kumar Sharma Featured Spotlight\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/wp.uthscsa.edu\/cpm\/#website\",\"url\":\"https:\/\/wp.uthscsa.edu\/cpm\/\",\"name\":\"Center for Precision Medicine\",\"description\":\"Center for Precision Medicine\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/wp.uthscsa.edu\/cpm\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dr. Kumar Sharma Featured Spotlight - Center for Precision Medicine","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/","og_locale":"en_US","og_type":"article","og_title":"Dr. Kumar Sharma Featured Spotlight - Center for Precision Medicine","og_description":"[vc_row][vc_column width=&#8221;2\/3&#8243;][vc_column_text]Dr. Sharma is an internationally renowned expert in kidney disease whose research has focused primarily on the pathogenesis of diabetic kidney disease (DKD). He has consistently taken a translational approach to research, utilizing animal and cell culture models to further our understanding of disease, testing hypotheses in clinical studies, and pursuing promising therapeutics in [&hellip;]","og_url":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/","og_site_name":"Center for Precision Medicine","article_modified_time":"2023-10-25T14:01:49+00:00","og_image":[{"url":"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133-285x400.jpg","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/","url":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/","name":"Dr. Kumar Sharma Featured Spotlight - Center for Precision Medicine","isPartOf":{"@id":"https:\/\/wp.uthscsa.edu\/cpm\/#website"},"primaryImageOfPage":{"@id":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#primaryimage"},"image":{"@id":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#primaryimage"},"thumbnailUrl":"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133-285x400.jpg","datePublished":"2021-04-16T16:53:47+00:00","dateModified":"2023-10-25T14:01:49+00:00","breadcrumb":{"@id":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#primaryimage","url":"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133.jpg","contentUrl":"https:\/\/wp.uthscsa.edu\/cpm\/wp-content\/uploads\/sites\/242\/2021\/04\/1353aa1307010540724415133.jpg","width":321,"height":450},{"@type":"BreadcrumbList","@id":"https:\/\/wp.uthscsa.edu\/cpm\/dr-kumar-sharma-featured-spotlight\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/wp.uthscsa.edu\/cpm\/"},{"@type":"ListItem","position":2,"name":"Dr. Kumar Sharma Featured Spotlight"}]},{"@type":"WebSite","@id":"https:\/\/wp.uthscsa.edu\/cpm\/#website","url":"https:\/\/wp.uthscsa.edu\/cpm\/","name":"Center for Precision Medicine","description":"Center for Precision Medicine","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/wp.uthscsa.edu\/cpm\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/wp.uthscsa.edu\/cpm\/wp-json\/wp\/v2\/pages\/455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.uthscsa.edu\/cpm\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.uthscsa.edu\/cpm\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.uthscsa.edu\/cpm\/wp-json\/wp\/v2\/users\/326"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.uthscsa.edu\/cpm\/wp-json\/wp\/v2\/comments?post=455"}],"version-history":[{"count":0,"href":"https:\/\/wp.uthscsa.edu\/cpm\/wp-json\/wp\/v2\/pages\/455\/revisions"}],"wp:attachment":[{"href":"https:\/\/wp.uthscsa.edu\/cpm\/wp-json\/wp\/v2\/media?parent=455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}