Kumar Sharma, MD

Chief of Nephrology
Professor of Medicine
sharmak3@uthscsa.edu

Dr. Sharma is an internationally renowned expert in kidney disease whose research has focused primarily on the pathogenesis of diabetic kidney disease (DKD). Dr. Sharma has consistently taken a translational approach to research, utilizing animal and cell culture models to further our understanding of disease, testing hypotheses in clinical studies, and pursuing promising therapeutics in clinical trials.  His laboratory helped define the central role of the cytokine Transforming Growth Factor-b (TGF-b) in DKD and contributed to the development of a highly innovative anti-fibrotic approach that was tested in a clinical research trial under Dr. Sharma’s guidance.  His group was also the first to describe the role of adiponectin in podocyte function and has been a major contributor to our understanding of the role of AMPK in DKD.  In 2013 Dr. Sharma’s group published a paradigm-shifting paper on superoxides in DKD which highlighted the impact of altered cellular metabolism on the disease process.  Recent studies with metabolomics have established a key role for mitochondrial dysfunction in DKD and have identified key metabolites whose levels are altered in DKD.    These metabolites may serve as biomarkers for individuals at risk for developing DKD, and current clinical studies to pursue this hypothesis are underway under Dr. Sharma’s leadership.

Shweta Bansal, MD

Associate Professor/Clinical
bansals3@uthscsa.edu

Madesh Muniswamy, PhD

Professor of Medicine
muniswamy@uthscsa.edu

Hongping Ye, PhD

Director Research Core Facility
yeh1@uthscsa.edu

Catherine Do, MD

Associate Professor/Clinical

doc@uthscsa.edu

Manjula Darshi, PhD

Associate Professor / Research
darshi@uthscsa.edu

Dr. Darshi is a biochemist with expertise in mitochondrial biology, mass spectrometry-based metabolomics, and cell and molecular biology working at the interface of basic research and translational research.  She is involved in multiple inter-disciplinary projects focused on addressing the mechanisms of diabetic kidney disease and identifying biomarkers for the prediction of disease development and progression and the development of therapeutics. Her current research interests are to identify predictive and mechanistic biomarkers and signaling pathways for metabolic diseases mainly due to mitochondrial dysfunctions. She employs a multi-omics approach (metabolomics, mass-spectrometrimy imaging, lipidomics, proteomics) to identify protein and metabolite biomarkers and animal and cell culture models and human samples to further study mitochondrial structural and functional mechanisms using Seahorse extracellular flux analyzer and oroboros O2K.

Guanshi Zhang, PhD

Associate Professor / Research
zhangg3@uthscsa.edu

Daniel Montemayor
PhD

Instructor/Research
montemayord2@uthscsa.edu

Subrata Debnath, PhD, MPH

Clinical Research Project Manager
nath@uthscsa.edu

Doug Lee, PhD

Post-Doctoral Fellow
leed@uthscsa.edu

Viktor Drel, PhD

Postdoctoral Fellow
drel@uthscsa.edu

John Kim, BS

Research Assistant
kimj15@uthscsa.edu

Samy Habib, PhD

Associate Professor / Research
habib@uthscsa.edu

Maggie Diamond-Stanic, PhD

Grants Specialist
diamondstani@uthscsa.edu