Contact

Location: 3.340D - MED

Department

Pathology

Wiederhold, Nathan P., Pharm.D.

Associate Professor, Director, Fungus Testing Laboratory

Research

Dr. Wiederhold’s research is focused on trends in antifungal resistance, new mechanisms of drug resistance in fungi, and in the evaluation of novel agents under development for the treatment of invasive fungal infections. The Fungus Testing Laboratory is an international reference mycology laboratory with both clinical and research missions.

The lab’s research focuses on the preclinical evaluation of investigational therapeutic modalities and diagnostic technologies for the diagnosis and treatment of fungal infections.  This includes both in vitro assessment for activity against a wide range of fungal pathogens, including multi-drug resistant clinical isolates, and in vivo models of invasive fungal infections.

This work is supported through NIH/NIAID contracts and grants from industry, and they collaborate closely with other researchers in the Departments of Microbiology and Immunology, Medicine/Infectious Diseases, and Pathology in these studies. They also serve as the central mycology laboratory for several clinical trials and post-marketing studies.

The lab’s groups are also interested in evaluating antifungal susceptibility results to determine changes in resistance patterns and in the discovery of novel mechanisms of antifungal resistance.  Several new species of fungi have also been discovered by the laboratory in collaboration with other international mycology laboratories, both through morphologic/phenotypic assessment and phylogenetic analysis.

Awards & Accomplishments

  • Appointed as a Voting member of the Clinical and Laboratory Standards Institute (CLSI) Antifungal Susceptibility Subcommittee (October 2015).
  • Outstanding Poster at the 6th Advances Against Aspergillosis Meeting, Madrid, Spain (February 2014). “Evaluation of the In vitro Potency of Itraconazole, Voriconazole, and Posaconazole, and Resistance in Aspergillus Isolates from the United States.

Affiliations

  • Member, American Society of Microbiology
  • Member, International Society of Human and Animal Mycology
  • Member, Infectious Diseases Society of Amercia
  • Member, American College of Clinical Pharmacy
  • Member, Society of Infectious Diseases Pharmacists

Publications

NCBI Complete List of Publications: http://www.ncbi.nlm.nih.gov/sites/myncbi/1zey9d8GojpA8/bibliography/47527854/public/?sort=date&direction=ascending

  • Yong LK, Wiederhold NP, Sutton DA, Sandoval-Denis M, Lindner JR, Fan H, Sanders C, Guarro J. Morphological and Molecular Characterization of Exophiala polymorpha, sp. nov., Isolated from Sporotrichoid Lymphocutaneous Lesions in a Patients with Myasthenia Gravis.  Journal of Clinical Microbiology 2015; 53: 2816-2822.
  • Eghrari AO, Gibas C, Watkins T, Vahedi S, Lee R, Houle E, Suarez MJ, Eberhart C, Sutton D, Wiederhold NP, Sikder S, Zhang SX. First Human Case of Fungal Keratitis Caused by a Putatively Novel Species of Lophotrichus. Journal of Clinical Microbiology 2015; 53: 3063-3067.
  • Levy AC, Rehman S, Sutton DA, Burris KI, Hirschwerk DA, Chen S, Wiederhold NP, Fan H, Lindner J, Bhaskaran M, Ali N, Ali NM, Rilo HL, Molmenti EP. A Case of Phaeohyphomycosis Caused by Exophiala oligosperma in a Renal Transplant Patient Successfully Treated with Posaconazole. American Journal of Infectious Diseases 2015; 11: 15-19.
  • Saracli MA, Fothergill AW, Sutton DA, Wiederhold NP. Detection of Triazole Resistance Among Candida Species by Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS). Medical Mycology 2015; 53: 736-742.
  • Sandoval-Denis M, Sutton DA, Martin-Vicente A, Cano-Lira JF, Wiederhold N, Guarro J, Gene J. Cladosporium Species Recovered from Clinical Samples in the United States. Journal of Clinical Microbiology 2015; 53: 2990-3000.
  • Shubitz LF, Hien TT, Galgiani JN, Lewis ML Fothergill AW, Wiederhold NP, Barker BM, Lewis ERG, Doyle AL, Hoekstra WJ, Schotzinger RJ, Garvey EP. Evaluation of VT-1161 for Treatment of Coccididoidomycosis in Murine Infection Models. Antimicrobial Agents and Chemotherapy 2015 (In Press).
  • Gebremarian T, Wiederhold NP, Fothergill AW, Garvey E, Hoekstra WJ, Schotzinger RJ, Patterson TF, Filler SG, Ibrahim AS. VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var arrhizus Infection. Antimicrobial Agents and Chemotherapy 2015 (In Press).
  • Sanchis M, Guarro J, Sutton DA, Fothergill AW, Wiederhold N, Capilla J. Voriconazole and Posaconazole Therapy for Experimental Candida lusitaniae Infection. Diagnostic Microbiology and Infectious Diseases 2015 (In Press).
  • Wiederhold NP, Garcia Gil V, Gutierrez F, Lindner JR, Albataineh, MT, McCarthy DI, Sanders C, Fan H, Fothergill AW, Sutton DA. First Detection of TR34/L98H and TR46/Y121F/T289A Cyp51 Mutations in Aspergillus fumigatus Isolates in the United States. Journal of Clinical Microbiology 2015 (In Press).
  • Wiederhold NP, Najvar LK, Fothergill AW, Bocanegra R, Olivo M, McCarthy DI, Fukuda Y, Mitsuyama J, Patterson TF. The Novel Arylamidine T-2307 Demonstrates In Vitro and In Vivo Activity Against Echinocandin Resistant Candida glabrata. Journal of Antimicrobial Chemotherapy 2015 (In Press).