{"id":343,"date":"2021-10-01T18:24:46","date_gmt":"2021-10-01T23:24:46","guid":{"rendered":"https:\/\/wp.uthscsa.edu\/structural-biology\/?page_id=343"},"modified":"2026-04-29T11:42:07","modified_gmt":"2026-04-29T16:42:07","slug":"publications","status":"publish","type":"page","link":"https:\/\/wp.uthscsa.edu\/structural-biology\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

[vc_row][vc_column width=”2\/3″][vc_column_text css=””]2026<\/strong><\/p>\n

Rawal Y, Kwon Y, Jia L, Ruben EA, Ji JH, Guo L, Stratton CM, Nayak D, Tovar M, Fang Q, Jamalruddin MA, Zhou S, Kuppa S, Syed S, Jasper AM, Katz JN, Rogers CM, Kaur H, Samentar L, Zhao W, Dray E, Zhang F, Stoilova-McPhie S, Taylor AB, Burma S, Rao MK, Libich DS, Hromas R, Mazin AV, Jasin M, Zhou D, Bernstein KA, Greene EC, Wasmuth EV, Sung P, Olsen SK. (2026). Structural insight into how RAD51 paralog exchange regulates RAD51 filament formation. Nat Struct Mol Biol<\/em>.doi: 10.1038\/s41594-026-01796-6. PDB: 9OMY<\/a>, 9OMZ<\/a>, 9ZZR<\/a>, 9ON2<\/a><\/p>\n

Nayak D, Jia L, Dos Santos Bury P, Ruben EA, Shukla A, Nayak A, Stratton CM, Ebadi P, Cho H, Tumanova AA, Varughese JT, Yuan L, Gao F, Cano KE, Davies C, Sung P, Gack MU, Wasmuth EV, Olsen SK. (2026). Cryo-EM structures of UBA6 reveal mechanisms of E1-E2 specificity and dual FAT10\/ubiquitin thioester transfer. Nat Commun<\/em>. 17<\/strong>, 3302. PDB: 9YKV<\/a>, 9YLB<\/a>, 9YKW<\/a>, 9YLF<\/a><\/p>\n

Dutta A, Ji JH, Syed S, Fang Q, Mukhopadhyay P, Wang H, Loranc E, Medina D, Abdulsahib S, Zhou S, Tovar M, Wang J, Benoit JM, Liang F, Tomimatsu N, Nyalwidhe JO, Dray E, Verway-Cohen A, McDonald DT, de la Pe\u00f1a Avalos B, Li W, Herrero AO, Fitzgerald O, Taylor AB, Kwon Y, Semmes OJ, Tsai MS, Rao M, Hromas R, Burma S, Chen Y, Mazin AV, Wasmuth E, Olsen SK, Zhou D, Bishop AJR, Zhao W, Kupfer GM, Sung P. (2026). Resolution of R-loops and transcription-replication conflicts by SETX-BRCA1-BARD1 complex. Nat Struct Mol Biol<\/em>. 33<\/strong>, 615-630.<\/p>\n

Sherwood LJ, Taylor AB, Olsen SK, Hayhurst A. (2026). Crystal Structure of M\u011bngl\u00e0 Virus Nucleoprotein Bound by a Poorly Cross-Reactive Anti-Marburg Virus Nanobody Highlights a Single Amino Acid Affinity Switch, a Feature Also Evident in Dehong Virus. ACS Infect Dis<\/em>. 12<\/strong>, 1104-1121. PDB: 10Z0<\/a><\/p>\n

2025<\/strong><\/p>\n

Nayak A, Nayak D, Jia L, Ruben EA, Viswanadhapalli S, Dos Santos Bury P, Nassar KM, Yu CH, Tumanova AA, Stratton CM, Ebadi P, Ivanov DN, Sung P, Vadlamudi RK, Wasmuth EV, Olsen SK. (2025). Cryo-EM structures reveal the molecular mechanism of SUMO E1-E2 thioester transfer. Nat Struct Mol Biol<\/em>. 32,<\/strong>\u00a02441-2453. PDB: 9DRJ<\/a>, 9DQB<\/a><\/p>\n

Alwan SN, Taylor AB, McHardy SF, Cameron MD, LoVerde PT. (2025). Development of a Novel Compound Effective Against Juvenile, Adult, and Drug-Resistant Schistosoma<\/em> Species. Pharmaceutics<\/em>. 17<\/strong>, 1268.<\/p>\n

Flury P, Vishwakarma J, Sylvester K, Higashi-Kuwata N, Dabrowska AK, Delgado R, Cuell A, Basu R, Taylor AB, de Oliveira EG, Magalh\u00e3es Serafim MS, Qiao J, Chen Y, Yang S, O’Donoghue AJ, Mitsuya H, G\u00fctschow M, Laufer SA, M\u00fcller CE, Harris RS, Pillaiyar T. (2025). Azapeptide-Based SARS-CoV-2 Main Protease Inhibitors: Design, Synthesis, Enzyme Inhibition, Structural Determination, and Antiviral Activity. J Med Chem<\/em>. 68<\/strong>, 19339-19376. PDB: 9MDQ<\/a><\/p>\n

Wieteska \u0141, Taylor AB, Punch E, Coleman JA, Conway IO, Lin Y-F, Byeon C-H, Hinck CS, Krzysiak T, Ishima R, L\u00f3pez-Casillas F, Cherepanov P, Bernard DJ, Hill CS, Hinck AP. (2025). Structures of TGF-\u03b2 with betaglycan and the signaling receptors reveal mechanisms of complex assembly and signaling. Nat Commun<\/em>. 26<\/strong>, 1778. PDB: 8DC0<\/a>, 9B9F<\/a><\/p>\n

Schwartze TA, Morosky SA, Rosato TL, Henrickson A, Lin G, Hinck CS, Taylor AB, Olsen SK, Calero G, Demeler B, Roman BL, Hinck AP. (2025). Molecular basis of interchain disulfide-bond formation in BMP-9 and BMP-10. J Mol Biol<\/em>. 437<\/strong>, 168935. PDB: 9DPY<\/a><\/p>\n

Parra GL, Sohn EJ, Xu X, Libich DS. (2025). The Spliceosomal Peptidyl Prolyl Isomerase Like 1 Interacts with the Low-Complexity Domain of the RNA Binding Protein EWS Modulating Its Phase Separation Behavior.\u00a0Biochemistry<\/em>.\u00a064<\/strong>, 3173-3177.<\/p>\n

Selig EE, Sohn EJ, Stoja A, Moreno-Romero AK, Akula S, Xu X, Bishop AJR, Libich DS. (2025). Phase separation of the oncogenic fusion protein EWS::FLI1 is modulated by its DNA-binding domain. Proc Natl Acad Sci U S A<\/em>. 122,<\/strong>\u00a0e2221823122.<\/p>\n

Baudin A, Dinh HH, Xu X, Libich DS. (2025). The 1H, 15N and 13C backbone resonance assignments of the N-terminal (1-149) domain of Serpine mRNA Binding Protein 1 (SERBP1). Biomol NMR Assign<\/em>. 19<\/strong>, 101-107.<\/p>\n

2024<\/strong><\/p>\n

Jia L, Ruben EA, Suarez HJ, Olsen SK, Wasmuth EV. (2024). Single particle cryo-electron microscopy with an enhanced 200 kV cryo-TEM configuration achieves near-atomic resolution. bioRxiv<\/em>. https:\/\/doi.org\/10.1101\/2024.05.07.593029<\/p>\n

Nayak D, Lv D, Yuan Y, Zhang P, Hu W, Nayak A, Ruben EA, Lv Z, Sung P, Hromas R, Zheng G, Zhou D, Olsen SK. (2024). Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun<\/em>. 15, <\/strong>2743. PDB: 8FY0<\/a>, 8FY1<\/a>, 8FY2<\/a><\/p>\n

Johnson CN, Sojitra KA, Sohn EJ, Moreno-Romero AK, Baudin A, Xu X, Mittal J, Libich DS. (2024) Insights into Molecular Diversity within the FUS\/EWS\/TAF15 Protein Family: Unraveling Phase Separation of the N-Terminal Low-Complexity Domain from RNA-Binding Protein EWS. J Am Chem Soc<\/em>. 146<\/strong>, 8071-8085.<\/p>\n

Suating P, Kimberly LB, Ewe MB, Chang SL, Fontenot JM, Sultane PR, Bielawski CW, Decato DA, Berryman OB, Taylor AB, Urbach AR. (2024). Cucurbit[8]uril Binds Nonterminal Dipeptide Sites with High Affinity and Induces a Type II \u03b2-Turn. J Am Chem Soc<\/em>. 146<\/strong>, 7649\u20137657. CCDC: 2312293<\/a>.<\/p>\n

2023<\/strong><\/p>\n

Jaiswal AS, Dutta A, Srinivasan G, Yuan Y, Zhou D, Shaheen M, Sadideen DT, Kirby A, Williamson EA, Gupta YK, Olsen SK, Xu M, Loranc E, Mukhopadhyay P, Pertsemlidis A, Bishop AJR, Sung P, Nickoloff JA, Hromas R. (2023). TATDN2 resolution of R-loops is required for survival of BRCA1-mutant cancer cells. Nucleic Acids Res<\/em>. 51<\/strong>, 12224-12241.<\/p>\n

Afsar M, Liu G, Jia L, Ruben EA, Nayak D, Sayyad Z, Bury PDS, Cano KE, Nayak A, Zhao XR, Shukla A, Sung P, Wasmuth EV, Gack MU, Olsen SK. (2023). Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun<\/em>. 14<\/strong>, 4786. PDB: 8SE9<\/a>, 8SEA<\/a>, 8SEB<\/a>, 8SV8<\/a>. Nature Structural & Molecular Biology<\/em> News and Views Article, February 6, 2024<\/a>.<\/p>\n

Rawal Y, Jia L, Meir A, Zhou S, Kaur H, Ruben EA, Kwon Y, Bernstein KA, Jasin M, Taylor AB, Burma S, Hromas R, Mazin AV, Zhao W, Zhou D, Wasmuth EV, Greene EC, Sung P, Olsen SK. (2023). Structural insights into BCDX2 complex function in homologous recombination. Nature<\/em>. 619<\/strong>, 640\u2013649. PDB: 8FAZ<\/a>, 8GBJ<\/a><\/p>\n

Alwan SN, Taylor AB, Rhodes J, Tidwell M, McHardy SF, LoVerde PT. (2023). Oxamniquine derivatives overcome Praziquantel treatment limitations for Schistosomiasis. PLOS Pathogens<\/em>. 19<\/strong>, e1011018. PDB: 8E5Q<\/a>, 8E5R<\/a><\/p>\n

Clark NE, Katolik A, Gallant P, Welch A, Murphy E, Buerer L, Schorl C, Naik N, Naik MT, Holloway SP, Cano K, Weintraub ST, Howard KM, Hart PJ, Jogl G, Damha MJ, Fairbrother WG. (2023). Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain. J Biol Chem<\/em>. 299<\/strong>, 105100.<\/p>\n

Amambua-Ngwa A, Button-Simons KA, Li X, Kumar S, Brenneman KV, Ferrari M, Checkley LA, Haile MT, Shoue DA, McDew-White M, Tindall SM, Reyes A, Delgado E, Dalhoff H, Larbalestier JK, Amato R, Pearson RD, Taylor AB, Nosten FH, D’Alessandro U, Kwiatkowski D, Cheeseman IH, Kappe SHI, Avery SV, Conway DJ, Vaughan AM, Ferdig MT, Anderson TJC. (2023). Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1. Nat Microbiol<\/em>. 8<\/strong>, 1213-1226.<\/p>\n

2022<\/strong><\/p>\n

Herkules F, Yu CH, Taylor AB, Dougherty V, Weintraub ST, Ivanov DN. (2022). Structural and functional asymmetry of RING trimerization controls priming and extension events in TRIM5\u03b1 autoubiquitylation. Nat Commun<\/em>. 13<\/strong>, 7104.<\/p>\n

Yuan L, Gao F, Lv Z, Nayak D, Nayak A, Santos Bury PD, Cano KE, Jia L, Oleinik N, Atilgan FC, Ogretmen B, Williams KM, Davies C, El Oualid F, Wasmuth EV, Olsen SK. (2022). Crystal structures reveal catalytic and regulatory mechanisms of the dual-specificity ubiquitin\/FAT10 E1 enzyme Uba6. Nat Commun<\/em>. 13<\/strong>, 4880. PDB: 7SOL<\/a><\/p>\n

Lv Z, Cano KE, Jia L, Drag M, Huang TT, Olsen SK. (2022). Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development. Front Chem<\/em>. 9<\/strong>, 819165.<\/p>\n

Clark NE, Katolik A, Welch A, Schorl C, Holloway SP, Schuermann JP, Hart PJ, Taylor AB, Damha MJ, Fairbrother WG. (2022). Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product. Biochemistry<\/em>. 61<\/strong>, 2933-2939. PDB: 8DZK<\/a><\/p>\n

Guzman MA, Rugel A, Alwan SN, Tarpley R, Taylor AB, Chevalier FD, Wendt GR, Collins JJ III, Anderson TJC, McHardy SF, LoVerde PT. (2022). Schistosome Sulfotransferases: Mode of Action, Expression and Localization. Pharmaceutics<\/em>. 14<\/strong>, 1416.<\/p>\n

Johnson CN, Xu X, Holloway SP, Libich DS. (2022) The 1H, 15N and 13C resonance assignments of the low-complexity domain from the oncogenic fusion protein EWS-FLI1.\u00a0Biomol NMR Assign<\/em>.\u00a016<\/strong>, 67-73.<\/p>\n

2021<\/strong><\/p>\n

Patchett S, Lv Z, Rut W, B\u00e9k\u00e9s M, Drag M, Olsen SK, Huang TT. (2021). A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep<\/em>. 36<\/strong>, 109754. PDB: 7LFU<\/a>, 7LFV<\/a><\/p>\n

Yuan L, Lv Z, Adams MJ, Olsen SK. (2021). Crystal structures of an E1-E2-ubiquitin thioester mimetic reveal molecular mechanisms of transthioesterification. Nat Commun<\/em>. 12<\/strong>, 2370. PDB: 7K5J<\/a><\/p>\n

LoVerde PT, Alwan SN, Taylor AB, Rhodes J, Chevalier FD, Anderson TJ, McHardy SF. (2021). Rational approach to drug discovery for human schistosomiasis. Int J Parasitol Drugs Drug Resist<\/em>. 16<\/strong>, 140-147.<\/p>\n

Sea KW, Taylor AB, Thomas ST, Liba A, Bergman IB, Holloway SP, Cao X, Gralla EB, Valentine JS, Hart PJ, Galaleldeen A. (2021). A pH Switch Controls Zinc Binding in Tomato Copper-Zinc Superoxide Dismutase. Biochemistry<\/em>. 60<\/strong>, 1597-1608. PDB: 3HOG<\/a>, 3KM1<\/a>, 3KM2<\/a>, 3MKG<\/a>, 3PU7<\/a>, 3S0P<\/a><\/p>\n

Yu CH, Bhattacharya A, Persaud M, Taylor AB, Wang Z, Bulnes-Ramos A, Xu J, Selyutina A, Martinez-Lopez A, Cano K, Demeler B, Kim B, Hardies SC, Diaz-Griffero F, Ivanov DN. (2021). Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun<\/em>. 12<\/strong>, 731. PDB: 6U6X<\/a>, 6U6Y<\/a>, 6U6Z<\/a><\/p>\n

Johnson CN, Libich DS. (2021) Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins. J Vis Exp<\/em>. 175<\/strong>, 10.3791\/63057.<\/p>\n

Baudin A, Moreno-Romero AK, Xu X, Selig EE, Penalva LOF, Libich DS. (2021) Structural Characterization of the RNA-Binding Protein SERBP1 Reveals Intrinsic Disorder and Atypical RNA Binding Modes. Mol Biosci<\/em>. \u00a08<\/strong>, 744707.<\/p>\n

Baudin A, Xu X, Libich DS. (2021) The 1H, 15N and 13C resonance assignments of the C-terminal domain of Serpine mRNA binding protein 1 (SERBP1). Biomol NMR Assign<\/em>. 15<\/strong>, 461-466<\/p>\n

2020<\/strong><\/p>\n

Guzman MA, Rugel A, Tarpley RS, Alwan SN, Chevalier FD, Kovalskyy D, Cao X, Holloway SP, Anderson TJC, Taylor AB, McHardy SF and LoVerde PT. An iterative process produces oxamniquine derivatives that kill all human schistosomes. (2020). PLOS Negl Trop Dis.<\/em> 14<\/strong>, e0008517.<\/p>\n

Rugel A, Guzman MA, Taylor AB, Chevalier FD, Tarpley RS, McHardy SF, Cao X, Holloway SP, Anderson TJC, Hart PJ and LoVerde PT. (2020). Why does oxamniquine kill Schistosoma mansoni<\/em> and not S. haematobium<\/em> and S. japonicum<\/em>? Int J Parasitol Drugs Drug Resist.<\/em> 13<\/strong>, 8-15. PDB: 6B4X<\/a>, 6B4Y<\/a>, 6B4Z<\/a>, 6B50<\/a>, 6B51<\/a>, 6B52<\/a>, 6B53<\/a>, 6B54<\/a><\/p>\n

Benavides BS, Valandro S, Taylor AB, Cioloboc D, Schanze KS, Kurtz Jr, DM. (2020). Structure of a Zinc Porphyrin-substituted Bacterioferritin and Photophysical Properties of Iron Reduction. Biochemistry<\/em>. 59<\/strong>, 1618-1629. PDB: 6P8K<\/a>,\u00a06P8L<\/a><\/p>\n

Guzman MA, Rugel A, Tarpley RS, Cao X, McHardy SF, LoVerde PT and Taylor AB. (2020). Molecular Basis for Hycanthone Drug Action in Schistosome Parasites. Mol Biochem Parasitol<\/em>. 236<\/strong>, 111257. PDB: 6UUX<\/a>,\u00a06UUY<\/a><\/p>\n

Wheeler R., Yu X., Hou C., Mitra P., Chen J.-M., Herkules F., Ivanov D.N., Tsodikov O.V., Rohr J. (2020) Discovery of a Cryptic Intermediate in Late Steps of Mithramycin Biosynthesis. Angew Chem Int Ed Engl<\/em>. 59<\/strong>, 826-832<\/p>\n

2019<\/strong><\/p>\n

Chevalier FD, Le Clec\u2019h W, McDew-White M, Menon V, Guzman M, Holloway SP, Cao X, Taylor AB, Kinungi S, Gouvras A, Webster B, Webster J, Emery AM, Rollinson D, Al Yafae S, Idris MA, Mon\u00e9 H, Mouahid G, Hart PJ, LoVerde PT and Anderson JC. (2019). Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni<\/em> and predate drug deployment. PLOS Pathogens<\/em>. 15<\/strong>, e1007881.<\/p>\n

Sherwood LJ, Taylor AB, Hart PJ and Hayhurst A. (2019). Paratope duality and gullying are among the atypical recognition mechanisms employed by a trio of nanobodies to differentiate ebolavirus nucleoproteins. J Mol Biol<\/em>. 431<\/strong>, 4848-4867. PDB: 6U50<\/a>,\u00a06U51<\/a>,\u00a06U52<\/a>,\u00a06U53<\/a>,\u00a06U54<\/a>,\u00a06U55<\/a><\/p>\n

Kim SK, Whitley MJ, Krzysiak TC, Hinck CS, Taylor AB, Zwieb C, Byeon C-H, Zhou X, Mendoza V, L\u00f3pez-Casillas F, Furey W, Hinck AP. (2019). Structural adaptation in its orphan domain engenders betaglycan with an alternate mode of growth factor binding relative to endoglin. Structure<\/em>. 27<\/strong>, 1427-1442. PDB: 6MZN<\/a>,\u00a06MZP<\/a><\/p>\n

Balasubramanian S, Pandranki L, Maupin S, Ramasamy K, Taylor AB, Hart PJ, Baseman JB, Kannan TR. (2019). Disulfide bond of Mycoplasma pneumoniae<\/em> community acquired respiratory distress syndrome toxin is essential to maintain the ADP-ribosylating and vacuolating activities. Cell Microbiol<\/em>. 21<\/strong>, e13032.<\/p>\n

Archer CR, Enslow BT, Taylor AB, De la Rosa V, Bhattacharya A, Shapiro MS. A mutually induced conformational fit underlies Ca2+-directed interactions between calmodulin and the proximal C terminus of KCNQ4 K+ channels. J Biol Chem<\/em>. 294<\/strong>, 6094-6112. PDB: 6N5W<\/a><\/p>\n

Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP. (2019) TGF-\u03b22 uses the concave surface of its extended finger region to bind betaglycan’s ZP domain via three residues specific to TGF-\u03b2 and inhibin-\u03b1. J Biol Chem<\/em>. 294<\/strong>, 3065-3080<\/p>\n

2018<\/strong><\/p>\n

Rugel A, Tarpley RS, Lopez A, Menard T, Guzman MA, Taylor AB, Cao X, Kovalskyy D, Chevalier F, Anderson TJ, Hart PJ, LoVerde PT, McHardy SF. (2018). Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Anti-Schistosomal Agents. ACS Med Chem Lett<\/em>. 9<\/strong>, 967-973. PDB: 6BDP<\/a>,\u00a06BDQ<\/a>,\u00a06BDR<\/a>,\u00a06BDS<\/a>,\u00a06MFE<\/a><\/p>\n

Katti S, Her B, Srivastava AK, Taylor AB, Lockless SW, Igumenova TI. (2018). High affinity interactions of Pb2+\u00a0with synaptotagmin I. Metallomics<\/em>.\u00a010<\/strong>, 1211-1222. PDB: 5VFE<\/a>,\u00a05VFF<\/a>,\u00a05VFG<\/a><\/p>\n

Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, Zimmer B, Sakata S, Dinis A, Ohara O, Garcia Reino EJ, Dobbs K, Hasek M, Holloway SP, McCammon K, Hussong SA, DeRosa N, Van Skike CE, Katolik A, Lorenzo L, Hyodo M, Faria E, Halwani R, Fukuhara R, Smith GA, Galvan V, Damha MJ, Al-Muhsen S, Itan Y, Boeke JD, Notarangelo LD, Studer L, Kobayashi M, Diogo L, Fairbrother WG, Abel L, Rosenberg BR, Hart PJ, Etzioni A, Casanova JL. (2018). Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell<\/em>.\u00a0172<\/strong>, 952-965.<\/p>\n

Ramasamy K, Balasubramanian S, Manickam K, Pandranki L, Taylor AB, Hart PJ, Baseman JB, Kannan TR. (2018). Mycoplasma pneumoniae<\/em>\u00a0Community-acquired Respiratory Distress Syndrome Toxin Uses a Novel KELED Sequence for Retrograde Transport and Subsequent Cytotoxicity.\u00a0MBio<\/em>.\u00a09<\/strong>, e01663-17.<\/p>\n

Yi C, Li G, Ivanov DN, Wang Z, Velasco MX, Hern\u00e1ndez G, Kaundal S, Villarreal J, Gupta YK, Qiao M, Hubert CG, Hart MJ, Penalva LOF. (2018) Luteolin inhibits Musashi1 binding to RNA and disrupts cancer phenotypes in glioblastoma cells. RNA Biol<\/em>. 15<\/strong>, 1420-1432.<\/p>\n

Wang Z, Bhattacharya A, White T, Buffone C, McCabe A, Nguyen LA, Shepard CN, Pardo S, Kim B, Weintraub ST, Demeler B, Diaz-Griffero F, Ivanov DN. (2018) Functionality of Redox-Active Cysteines Is Required for Restriction of Retroviral Replication by SAMHD1. Cell Rep<\/em>. 24<\/strong>, 815-823.<\/p>\n

Narasimhan R, Coras R, Rosenthal SB, Sweeney SR, Lodi A, Tiziani S, Boyle D, Kavanaugh A, Guma M. (2018) Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis. Arthritis Res Ther<\/em>. 20<\/strong>, 164.<\/p>\n

Brenner A, Zuniga R, Sun JD, Floyd J, Hart CP, Kroll S, Fichtel L, Cavazos D, Caflisch L, Gruslova A, Huang S, Liu Y, Lodi A, Tiziani S. (2018) Hypoxia Activated Evophosphamide for Treatment of Recurrent Bevacizumab-Refractory Glioblastoma: A phase I surgical study. Neuro Oncol<\/em>. 20<\/strong>, 1231-1239.<\/p>\n

Bryant JD, Sweeney SR, Sentandreu E, Shin M, Ipas H, Xhemalce B, Momb J, Tiziani S, Appling DR. (2018) Deletion of the neural tube defect-associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos. J Biol Chem<\/em>. 293<\/strong>, 5821-5833.<\/p>\n

2017<\/strong><\/p>\n

Garza JA, Taylor AB, Sherwood LJ, Hart PJ, Hayhurst A. (2017). Unveiling a drift resistant cryptotope within Marburgvirus nucleoprotein recognized by llama single domain antibodies.\u00a0Front Immunol<\/em>.\u00a08<\/strong>, 1234.\u00a0PDB:\u00a04W2O<\/a>,\u00a04W2P<\/a>,\u00a04W2Q<\/a>,\u00a06APO<\/a>,\u00a06APP<\/a>,\u00a06APQ<\/a><\/p>\n

Choi JY, Fuerst R, Knapinska AM, Taylor AB, Smith L, Cao X, Hart PJ, Fields GB, Roush WR. (2017). Structure-Based Design and Synthesis of Potent and Selective Matrix Metalloproteinase 13 Inhibitors. J Med Chem<\/em>. 60<\/strong>, 5816-5825. PDB: 5UWK<\/a>,\u00a05UWL<\/a>,\u00a05UWM<\/a>,\u00a05UWN<\/a><\/p>\n

Fetherolf MM, Boyd SD, Taylor AB, Blackburn NJ, Hart PJ, Winge DR, Winkler DD. (2017). Copper-Zinc Superoxide Dismutase is Activated through a Sulfenic Acid Intermediate at a Copper-ion Entry Site.\u00a0J Biol Chem<\/em>. 292<\/strong>, 12025-12040. PDB:\u00a05U9M<\/a><\/p>\n

Taylor AB, Roberts KM, Cao X, Clark NE, Holloway SP, Donati E, Polcaro CM, Pica-Mattoccia L, Tarpley RS, McHardy SF, Cioli D, LoVerde PT, Fitzpatrick PF, Hart PJ. (2017). Structural and Enzymatic Insights into Species-specific Resistance to Schistosome Parasite Drug Therapy. J Biol Chem<\/em>. 292<\/strong>, 11154-1164. PDB: 5TIV<\/a>,\u00a05TIW<\/a>,\u00a05TIX<\/a>,\u00a05TIY<\/a>,\u00a05TIZ<\/a><\/p>\n

Katti S, Nyenhuis SB, Her B, Srivastava AK, Taylor AB, Hart PJ, Cafiso DS, Igumenova TI. (2017). Non-native metal ion reveals the role of electrostatics in Synaptotagmin 1-membrane interactions. Biochemistry<\/em>. 56<\/strong>, 3283-3295. PDB: 5T0R<\/a>,\u00a05T0S<\/a><\/p>\n

Kim SK, Myers L, Hinck CS, Cano K, Thirangala A, Iskra B, Brothers M, Vonberg M, Leal B, Richter B, Kodali R, Taylor AB, Du S, Barnes C, Calero G, Hart PJ, Hart MJ, Demeler B, Hinck AP. (2017). An Engineered TGF-beta Monomer that Functions as a Dominant Negative to Block TGF-beta Signaling. J Biol Chem<\/em>. 292<\/strong>, 7173-7188. PDB: 5TX2<\/a>,\u00a05TX4<\/a>,\u00a05TX6<\/a>\u00a0Editor\u2019s Pick<\/p>\n

Katolik A, Clark NE, Tago N, Montemayor EJ, Hart PJ, Damha MJ. (2017). Fluorescent Branched RNAs for High-throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition.\u00a0ACS Chem Biol<\/em>.\u00a012<\/strong>, 622-627.<\/p>\n

2016<\/strong><\/p>\n

Clark NE, Katolik A, Roberts KM, Taylor AB, Holloway SP, Schuermann JP, Montemayor EJ, Stevens SW, Fitzpatrick PF, Damha MJ, Hart PJ. (2016). Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1.\u00a0Proc Natl Acad Sci<\/em>.\u00a0113<\/strong>, 14727-14732. PDB:\u00a05K71<\/a>,\u00a05K73<\/a>,\u00a05K77<\/a>,\u00a05K78<\/a><\/p>\n

Ayers JI, Diamond J, Sari A, Fromholt S, Galaleldeen A, Ostrow LW, Glass JD, Hart PJ, Borchelt DR. (2016). Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS.\u00a0Acta Neuropathol<\/em>.\u00a0132<\/strong>, 827-840.<\/p>\n

Wong SJ, Gearhart MD, Taylor AB, Nanyes DR, Ha DJ, Robinson AK, Artigas JA, Lee OJ, Demeler B, Hart PJ, Bardwell VJ, Kim CA. (2016). KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1.\u00a0Structure<\/em>.\u00a024<\/strong>, 1795-1801. PDB:\u00a05JH5<\/a><\/p>\n

Peterson RL, Galaleldeen A, Villarreal J, Taylor AB, Cabelli DE, Hart PJ, Culotta VC. (2016). The Phylogeny and Active Site Design of Eukaryotic Cu-only Superoxide Dismutases. J Biol Chem<\/em>. 291<\/strong>, 20911-20923. PDB: 5KBK<\/a>,\u00a05KBL<\/a>,\u00a05KBM<\/a><\/p>\n

Chevalier FD, Le Clec\u2019h W, Eng N, Rugel AR, de Assis RR, Oliveira G, Holloway SP, Cao X, Hart PJ, LoVerde PT, Anderson TJ.\u00a0(2016). Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population.\u00a0Int J Parisitol<\/em>.\u00a046<\/strong>, 417-424.<\/p>\n

Meisburger SP, Taylor AB, Khan CA, Zhang S, Fitzpatrick PF, Ando N.\u00a0(2016).\u00a0Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering.\u00a0J Am Chem Soc<\/em>.\u00a0138<\/strong>, 6506-6516.\u00a0PDB:\u00a05EGQ<\/a>,\u00a05FGJ<\/a><\/p>\n

Wu X, Kim H, Seravalli J, Barycki JJ, Hart PJ, Gohara DW, Di Cera E, Jung WH, Kosman DJ, Lee J.\u00a0(2016).\u00a0Potassium and the K+\/H+\u00a0Exchanger Kha1p Promote Binding of Copper to Apo-Fet3p Multi-Copper Ferroxidase.\u00a0J Biol Chem<\/em>.\u00a0291<\/strong>, 9796-9806.<\/p>\n

2015<\/strong><\/p>\n

Taylor AB, Pica-Mattoccia L, Polcaro CM, Donati E, Cao X, Basso A, Guidi A, Rugel AR, Holloway SP, Anderson TJ, Hart PJ, Cioli D, and LoVerde PT.\u00a0(2015). Structural and functional characterization of the enantiomers of the antischistosomal drug oxamniquine.\u00a0PloS Negl Trop Dis<\/em>.\u00a09<\/strong>, e0004132. PDB:\u00a05BYJ<\/a>,\u00a05BYK<\/a><\/p>\n

Tago N, Katolik A, Clark NE, Montemayor EJ, Seio K, Sekine M, Hart PJ, and Dahma MJ.\u00a0(2015). Design, Synthesis, and Properties of Phosphoramidate 2\u2032,5\u2032-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme.\u00a0J Org Chem.<\/em>\u00a080<\/strong>, 10108-10118.<\/p>\n

Yudina Z, Roa A, Johnson R, Biris N, de Souza Aranha Vieira A, Tsiperson V, Reszka N, Taylor AB, Hart PJ, Demeler B, Diaz-Griffero F, and Ivanov DN.\u00a0(2015). RING dimerization links higher-order assembly of TRIM5\u03b1 to synthesis of K63-linked polyubiquitin.\u00a0Cell Reports<\/em>.\u00a012<\/strong>, 788-797. PDB:\u00a04TKP<\/a><\/p>\n

Becker A, Kannan TR, Taylor AB, Pakhomova ON, Zhang Y, Somarajan SR, Galaleldeen A, Holloway SP, Baseman JB, and Hart PJ.\u00a0(2015). Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from\u00a0Mycoplasma pneumoniae<\/em>.\u00a0Proc Natl Acad Sci<\/em>.\u00a0112<\/strong>, 5165-5170. PDB:\u00a04TLV<\/a>,\u00a04TLW<\/a><\/p>\n

Sea K, Sohn SH, Durazo A, Sheng Y, Shaw BF, Cao X, Taylor AB, Whitson LJ, Holloway SP, Hart PJ, Cabelli DE, Gralla EB, Valentine JS.\u00a0(2015). Insights into the Role of the Unusual Disulfide Bond in Copper-Zinc Superoxide Dismutase.\u00a0J Biol Chem<\/em>.\u00a0290<\/strong>, 2405-2418. PDB:\u00a04MCM<\/a>,\u00a04MCN<\/a><\/p>\n

2014<\/strong><\/p>\n

Bhattacharya A, Alam SL, Fricke T, Zadrozny K, Sedzicki J, Taylor AB, Demeler B, Pornillos O, Ganser-Pornillos BK, Diaz-Griffero F, Ivanov DN, Yeager M.\u00a0(2014). Structural basis of HIV-1 capsid recognition by PF74 and CPSF6.\u00a0Proc Natl Acad Sci<\/em>.\u00a0111<\/strong>, 18625-18630. PDB:\u00a04WYM<\/a><\/p>\n

Spicer TP, Jiang J, Taylor AB, Choi JY, Hart PJ, Roush WR, Fields GB, Hodder PS, Minond D.(2014). Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation In Vitro.\u00a0J Med Chem<\/em>.\u00a057<\/strong>, 9598-9611. PDB:\u00a04L19<\/a><\/p>\n

Montemayor EJ, Katolik A, Clark NE, Taylor AB, Schuermann JP, Combs DJ, Johnsson R, Holloway SP, Stevens SW, Damha MJ, Hart PJ. (2014). Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Res<\/em>. 42<\/strong>, 10845-10855. PDB: 4PEF<\/a>, 4PEG<\/a>, 4PEH<\/a>, 4PEI<\/a>, NAR Breakthrough Article.<\/p>\n

Nanyes DR, Junco SE, Taylor AB, Robinson AK, Patterson NL, Shivarajpur A, Halloran J, Hale SM, Kaur Y, Hart PJ, Kim CA.\u00a0(2014). Multiple polymer architectures of human polyhomeotic homolog 3 sterile alpha motif.\u00a0Proteins<\/em>.\u00a082<\/strong>, 2823-2830. PDB:\u00a04PZN<\/a>,\u00a04PZO<\/a><\/p>\n

Kannan TR, Krishnan M, Ramasamy K, Becker A, Pakhomova ON, Hart PJ, Baseman JB.\u00a0(2014). Functional mapping of community-acquired respiratory distress syndrome (CARDS) toxin of\u00a0Mycoplasma pneumoniae<\/em>\u00a0defines regions with ADP-ribosyltransferase, vacuolating and receptor-binding activities.\u00a0Mol Microbiol<\/em>.\u00a093<\/strong>, 568-581.<\/p>\n

Ayers JI, Xu G, Pletnikova O, Troncoso JC, Hart PJ, Borchelt DR.\u00a0(2014). Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases.\u00a0Acta Neuropathol Commun<\/em>. 2<\/strong>, 55.<\/p>\n

Gleason JE, Galaleldeen, A, Peterson RL, Taylor AB, Holloway SP, Waninger-Saroni J, Cormack BP, Cabelli DE, Hart PJ, Culotta VC. (2014). Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense. Proc Natl Acad Sci<\/em>. 111<\/strong>, 5866-5871. PDB:\u00a04N3T<\/a>,\u00a04N3U<\/a><\/p>\n

Katolik A, Johnsson R, Montemayor E, Lackey JG, Hart PJ, Damha MJ.\u00a0(2014). Regiospecific Solid-phase Synthesis of Branched Oligoribonucleotides that Mimic Intronic Lariat RNA Intermediates.\u00a0J Org Chem<\/em>.\u00a079<\/strong>, 963-975.<\/p>\n

Ivanova MI, Sievers SA, Guenther EL, Johnson LM, Winkler DD, Galaleldeen A, Sawaya MR, Hart PJ, Eisenberg DS.\u00a0(2014). Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS.\u00a0Proc Natl Acad Sci<\/em>.\u00a0111<\/strong>, 197-201.<\/p>\n

2013<\/strong><\/p>\n

Valentim CL, Cioli D, Chevalier FD, Cao X, Taylor AB, Holloway SP, Pica-Mattoccia L, Guidi A, Basso A, Tsai IJ, Berriman M, Carvalho-Queiroz C, Almeida M, Aguilar H, Frantz DE, Hart PJ, LoVerde PT, Anderson TJ. (2013). Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites.\u00a0Science<\/em>.\u00a0342<\/strong>, 1385-1389. PDB:\u00a04MUA<\/a>,\u00a04MUB<\/a><\/p>\n

Morales KA, Yang Y, Long Z, Li P, Taylor AB, Hart PJ, Igumenova TI. (2013). Cd2+\u00a0as a Ca2+Surrogate in Protein-membrane Interactions: Isostructural but not Isofunctional.\u00a0J Am Chem Soc<\/em>.\u00a0135<\/strong>, 12980-12983.PDB:\u00a04L1L<\/a><\/p>\n

Galaleldeen A, Taylor AB, Chen D, Schuermann JP, Holloway SP, Hou S, Gong S, Zhong G, Hart PJ. (2013). Structure of the Chlamydia trachomatis Immunodominant Antigen Pgp3. J Biol Chem<\/em>. 288<\/strong>, 22068-22079. PDB: 4JDM<\/a>, 4JDN<\/a>, 4JDO<\/a> in ASBMB Today September 2013.<\/p>\n

Gaweska, HM, Taylor AB, Hart PJ, Fitzpatrick PF. (2013). The Structure of the Flavoprotein Tryptophan-2-Monooxygenase, a Key Enzyme in the Formation of Galls in Plants.\u00a0Biochemistry<\/em>.\u00a052<\/strong>, 2620-2626.PDB:\u00a04IV9<\/a><\/p>\n

Junco SE, Wang R, Gaipa JC, Taylor AB, Schirf V, Gearhart MD, Bardwell VJ, Demeler B, Hart, PJ, Kim CA. (2013). Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs. Structure<\/em>. 21<\/strong>, 665-671. PDB: 4HPL<\/a>,\u00a04HPM<\/a><\/p>\n

Aguirre JD, Clark HM, McIlvin M, Vazquez C, Palmere SL, Grab D, Seshu J, Hart PJ, Saito M, Culotta VC. (2013). A Manganese-rich Environment Supports Superoxide Dismutase Activity in a Lyme Disease Pathogen, Borrelia burgdorferi. J Biol Chem<\/em>. 288<\/strong>, 8468-8478.<\/p>\n

2012<\/strong><\/p>\n

Adachi MS, Taylor AB, Hart PJ, Fitzpatrick PF. (2012). Mechanistic and Structural Analyses of the Roles of Active Site Residues in the Yeast Polyamine Oxidase Fms1: Characterization of the N195A and D94N Enzymes.\u00a0Biochemistry<\/em>.\u00a051<\/strong>, 8690-8697.\u00a0PDB:\u00a04GDP<\/a><\/p>\n

Fang H, Caranto JD, Mendoza R, Taylor AB, Hart PJ, Kurtz Jr DM.(2012). Histidine ligand variants of a flavo-diiron protein: Effects on structure and activities. J Biol Inorg Chem<\/em>. 17<\/strong>, 1231-1239. PDB: 4DIK<\/a>,\u00a04DIL<\/a><\/p>\n

Biris N, Yang Y, Taylor AB, Tomashevski A, Guo M, Hart PJ, Diaz-Griffero F, Ivanov DN. (2012). Structure of the rhesus monkey TRIM5\u03b1 PRYSPRY domain, the HIV capsid recognition module.\u00a0Proc Nat Acad Sci<\/em>.\u00a0109<\/strong>, 13278-13283.\u00a0PDB:\u00a03UV9<\/a>,\u00a02LM3<\/a>\u00a0in\u00a0Protein Data Bank Molecule of the Month\u00a0July 2013<\/p>\n

Adachi MS, Taylor AB, Hart PJ, Fitzpatrick PF. (2012). Mechanistic and Structural Analyses of the Role of His67 in the Yeast Polyamine Oxidase Fms1. Biochemistry<\/em>. 51<\/strong>, 4888-4897. PDB: 4ECH<\/a><\/p>\n

Bouldin SD, Darch MA, Hart PJ, Outten CE. (2012). Redox properties of the disulfide bond of human Cu,Zn superoxide dismutase and the effects of human glutaredoxin 1. Biochem J<\/em>. 446<\/strong>, 59-67.<\/p>\n

Leitch JM, Li CX, Baron JA, Matthews LM, Cao X, Hart PJ, Culotta VC. (2012). Post-translational modification of Cu\/Zn superoxide dismutase under anaerobic conditions.\u00a0Biochemistry<\/em>.\u00a051<\/strong>, 677-685.<\/p>\n

2011<\/strong><\/p>\n

Pau VPT, Smith FJ, Taylor AB, Parfenova LV, Samakai E, Callaghan MM, Abarca-Heidemann K, Hart PJ, and Rothberg BS. (2011). Structure and function of Multiple Ca2+-binding sites in a K+\u00a0channel RCK domain.\u00a0Proc Natl Acad Sci<\/em>.\u00a0108<\/strong>, 17684-17689. PDB:\u00a03RBX<\/a>,\u00a03RBZ<\/a><\/p>\n

Childers BM, Cao X, Weber GG, Demeler B, Hart PJ, Klose KE. (2011). N-terminal residues of theVibrio cholerae\u00a0virulence regulatory protein ToxT involved in dimerization and modulation by fatty acids.\u00a0J Biol Chem<\/em>.\u00a0286<\/strong>, 28644-28655.<\/p>\n

Chinai JM, Taylor AB, Ryno LM, Hargreaves ND, Morris CA, Hart PJ, and Urbach AR. (2011). Molecular Recognition of Insulin by a Synthetic Receptor.\u00a0J Am Chem Soc<\/em>.\u00a0133<\/strong>, 8810-8813. PDB:\u00a03Q6E<\/a><\/p>\n

2010<\/strong><\/p>\n

Chen D, Lei L, Lu C, Galaleldeen A, Hart PJ, and Zhong G. (2010). Characterization of Pgp3, a Chlamydia trachomatis plasmid-encoded immunodominant antigen. J Bacteriol.<\/em> 192<\/strong>, 6017-6024.<\/p>\n

Seetharaman SV, Taylor AB, Holloway S, Hart PJ. (2010). Structures of mouse SOD1 and human\/mouse SOD1 chimeras.\u00a0\u00a0Arch Biochem Biophys<\/em>.\u00a0503<\/strong>, 183-190. PDB:\u00a03GTT<\/a>,\u00a03GTV<\/a>,\u00a03LTV<\/a><\/p>\n

Wang R, Taylor AB, Leal BZ, Chadwell LV, Ilangova U, Robinson AK, Schirf V, Hart PJ, Lafer EM, Demeler B, Hinck AP, McEwen DG, and Kim CA. (2010). Polycomb Group Targeting Through Different Binding Partners of RING1B C-terminal Domain. Structure<\/em>. 18<\/strong>, 966-975. PDB: 3GS2<\/a>,\u00a03IXS<\/a><\/p>\n

Seetharaman SV, Winkler DD, Taylor AB, Cao X, Whitson LJ, Doucette PA, Valentine JS, Schirf V, Demeler B, Carroll MC, Culotta VC, and Hart PJ. (2010). Disrupted Zinc-binding Sites in Structures of Pathogenic SOD1 Variants D124V and H80R.\u00a0\u00a0Biochemistry<\/em>. 49<\/strong>, 5714-5725.\u00a0 PDB: 3H2P<\/a>,\u00a03H2Q<\/a>,\u00a03H2R<\/a><\/p>\n

Tormos JR, Taylor AB, Daubner SC, Hart PJ, and Fitzpatrick PF. (2010).\u00a0 Identification of a Hypothetical Protein from Podospora anserina as a Nitroalkane Oxidase. Biochemistry<\/em>. 49<\/strong>, 5035-5031. PDB: 3MKH<\/a><\/p>\n

Pakhomova ON, Taylor AB, Becker A, Holloway SP, Kannan TR, Baseman JB, and Hart PJ. (2010).\u00a0 Crystallization of Community-acquired Respiratory Distress Syndrome Toxin from Mycoplasma pneumoniae<\/em>. Acta Cryst<\/em>. F66<\/strong>, 294-296.<\/p>\n

You Z, Cao X, Taylor AB, Hart PJ, and Levine, RL. (2010).\u00a0 Characterization of a Covalent Polysulfane Bridge in Copper-Zinc Superoxide Dismutase. Biochemistry<\/em>. 49<\/strong>, 1191-1198. PDB: 3K91<\/a><\/p>\n

2009<\/strong><\/p>\n

Galaleldeen A, Strange R, Whitson LJ, Antonyuk S, Narayana N, Taylor AB, Schuermann JP, Holloway SP, Hasnain SS, and Hart PJ.\u00a0 (2009).\u00a0 Structural and Biophysical Properties of Metal-Free Pathogenic SOD1 Mutants A4V and G93A.\u00a0\u00a0Arch Biochem Biophys<\/em>.\u00a0\u00a0492<\/strong>, 40-47.\u00a0 PDB:\u00a03GZO<\/a>,\u00a03GZP<\/a>,\u00a03GZQ<\/a>,\u00a02WKO<\/a><\/p>\n

Konkle ME, Muellner SK, Schwander AL, Dicus MM, Pokhrel R, Britt RD, Taylor AB, and Hunsicker-Wang LM. (2009).\u00a0 Effects of pH on the Rieske Protein from Thermus thermophilus: A Spectroscopic and Structural Analysis.\u00a0Biochemistry<\/em>.\u00a048<\/strong>, 9848-9857.\u00a0 PDB:\u00a03FOU<\/a><\/p>\n

Tiwari A, Liba A, Sohn SH, Seetharaman SV, Bilsel O, Matthews CR, Hart PJ, Valentine JS, and Hayward LJ.\u00a0 (2009).\u00a0 Metal deficiency increases aberrant hydrophobicity of mutant superoxide dismutases that cause amyotrophic lateral sclerosis.\u00a0\u00a0J Biol Chem<\/em>.\u00a0\u00a0284<\/strong>, 27746-27758.<\/p>\n

Seetharaman SV, Prudencio M, Karch C, Holloway SP, Borchelt DR, and Hart PJ. (2009).\u00a0 Immature copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.\u00a0Exp Biol Med<\/em>.\u00a0234<\/strong>, 1140-1154.<\/p>\n

Balasubramanian S, Kannan TR, Hart PJ, and Baseman JB. (2009). Amino acid changes in elongation factor Tu of Mycoplasma pneumoniae<\/em> and Mycoplasma genitalium<\/em> influence fibronectin binding. Infect Immun<\/em>. 77<\/strong>, 3533-3541.<\/p>\n

Leitch JM, Jensen LT, Bouldin SD, Outten CE, Hart PJ, and Culotta VC. (2009). Activation of Cu,Zn-superoxide dismutase in the absence of oxygen and the copper chaperone CCS.\u00a0J Biol Chem<\/em>.\u00a0284<\/strong>, 21863-21871.<\/p>\n

Prudencio M, Hart PJ, Borchelt DR, and Andersen PM. (2009). Variation in aggregation propensities among ALS-associated variants of SOD1: correlation to human disease.\u00a0Hum Mol Genet<\/em>.\u00a018<\/strong>, 3217-3226.<\/p>\n

Karch CM, Prudencio M, Winkler DD, Hart PJ, and Borchelt DR. (2009). Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS.\u00a0Proc Natl Acad Sci<\/em>.\u00a0106<\/strong>, 7774-7779.<\/p>\n

Chen D, Chai J, Hart PJ, and Zhong G. (2009). Identifying catalytic residues in CPAF, a Chlamydia-secreted protease.\u00a0Arch Biochem Biophys<\/em>.\u00a0\u00a0485<\/strong>, 16-23.<\/p>\n

Winkler DD, Schuermann JP, Cao X, Holloway SP, Borchelt DR, Carroll MC, Proescher JB, Culotta VC, and Hart PJ. (2009). Structural and biophysical properties of the pathogenic SOD1 variant H46R\/H48Q.\u00a0Biochemistry<\/em>.\u00a048<\/strong>, 3436-3447. PDB:\u00a03GQF<\/a><\/p>\n

2008<\/strong><\/p>\n

Schuermann JP, Jiang J, Cuellar J, Llorca O, Wang L, Gimenez LE, Jin S, Taylor AB, Demeler B, Morano KA, Hart PJ, Valpuesta JM, Lafer EM, and Sousa, R. (2008).\u00a0 Structure of the Hsp110:Hsc70 nucleotide exchange machine. Mol Cell.<\/em> 31<\/strong>, 232-243. PDB: 3C7N<\/a><\/p>\n

Cao X, Antonyuk S, Seetharaman SV, Whitson LJ, Taylor AB, Holloway SP, Strange RW, Doucette PA, Valentine JS, Tiwari A, Hayward LJ, Padua S, Cohlberg JA, Hasnain SS, and Hart PJ. (2008). Structures of the G85R variant of SOD1 in Familial ALS. J Biol Chem<\/em>. 283<\/strong>, 16169-16177. PDB: 2VR6<\/a>, 2VR7<\/a>, 2VR8<\/a>, 3CQP<\/a>, 3CQQ<\/a><\/p>\n

Taylor AB, Meyer B, Leal BZ, K\u00f6tter P, Schirf V, Demeler B, Hart PJ, Entian KD, and W\u00f6hnert, J.\u00a0 (2008). The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site.\u00a0\u00a0Nucleic Acids Res<\/em>.\u00a036<\/strong>, 1542-1554.\u00a0 PDB:\u00a03BBD<\/a>,\u00a03BBE<\/a>,\u00a03BBH<\/a><\/p>\n

Taylor AB, Hu G, Hart PJ, and McAlister-Henn L. (2008). Allosteric motions in structures of yeast NAD+-specific isocitrate dehydrogenase.\u00a0\u00a0J Biol Chem<\/em>.\u00a0\u00a0283<\/strong>, 10872-10880.\u00a0 PDB:\u00a03BLV<\/a>,\u00a03BLW<\/a>,\u00a03BLX<\/a>\u00a0in\u00a0Protein Data Bank Molecule of the Month\u00a0September 2010,\u00a0October 2012<\/p>\n

Groppe J, Hinck CS, Samavarchi-Tehrani P, Zubieta C, Schuermann JP, Taylor AB, Schwarz PM, Wrana JL, and Hinck, AP.\u00a0 (2008). Cooperative assembly of TGF-\u03b2\u00a0superfamily signaling complexes Is mediated by two disparate mechanisms and distinct modes of receptor binding.\u00a0\u00a0Mol Cell<\/em>.\u00a029<\/strong>, 157-168.\u00a0 PDB:\u00a02PJY<\/a><\/p>\n

2007<\/strong><\/p>\n

Quintanar L, Stoj C, Taylor AB, Hart PJ, Kosman DJ, and Solomon EI. (2007). Shall we dance? How a multicopper oxidase chooses its electron transfer partner. Acc Chem Res<\/em>. 40<\/strong>, 445-452.<\/p>\n

Jiang J, Maes EG, Taylor AB, Wang L, Hinck AP, Lafer EM, and Sousa, R.\u00a0 (2007). Structural basis of J cochaperone binding and regulation of Hsp70. Mol Cell.<\/em>\u00a0\u00a028<\/strong>, 422-433. PDB: 2QW9<\/a>,\u00a02QWL<\/a>,\u00a02QWM<\/a>,\u00a02QWN<\/a>,\u00a02QWO<\/a>,\u00a02QWP<\/a>,\u00a02QWQ<\/a>,\u00a02QWR<\/a><\/p>\n

Hu G, Taylor AB, McAlister-Henn L, and Hart PJ. (2007). Crystal structure of the yeast nicotinamidase Pnc1p.\u00a0\u00a0Arch Biochem Biophys<\/em>.\u00a0\u00a0461<\/strong>, 66-75.\u00a0 PDB:\u00a02H0R<\/a><\/p>\n

Galaleldeen A and Hart PJ. (2007) \u201cHuman copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis\u201d in:\u00a0Protein Reviews: Protein Misfolding, Aggregation and Conformational Diseases.\u00a0(Atassi, M.Z. ed.). Springer Science + Business Media, LLC, New York, U.S.A., pp. 327-344.<\/p>\n

Wang J, Caruano-Yzermans A, Rodriguez A, Schuermann JP, Slunt HH, Cao X, Gitlin J, Hart PJ, and Borchelt DR. (2007). Disease-associated mutations at copper ligand histidine residues of superoxide dismutase 1 diminish the binding of copper and compromise dimer stability.\u00a0\u00a0J Biol Chem<\/em>.\u00a0\u00a0282<\/strong>, 345-352.\u00a0 PDB:\u00a02NNX<\/a><\/p>\n

2006<\/strong><\/p>\n

Heitmann LM, Taylor AB, Hart PJ, and Urbach AR.\u00a0 (2006).\u00a0 Sequence-specific recognition and cooperative dimerization of N-terminal aromatic peptides in aqueous solution by a synthetic host.\u00a0\u00a0J Am Chem Soc<\/em>.\u00a0\u00a0128<\/strong>, 12574-12581.<\/p>\n

Carroll MC, Outten CE, Proescher JB, Rosenfeld L, Watson WH, Whitson LJ, Hart PJ, Jensen LT, and Culotta VC. (2006). The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase.\u00a0\u00a0J Biol Chem<\/em>.\u00a0\u00a0281<\/strong>, 28648-28656.<\/p>\n

Hart PJ.\u00a0 (2006).\u00a0 Pathogenic superoxide dismutase structure, folding, aggregation and turnover.\u00a0\u00a0Curr Opin Chem Biol.<\/em>\u00a010<\/strong>, 131-138.<\/p>\n

Jiang J, Lafer EM, and Sousa R. (2006). Crystallization of a functionally intact Hsp70 chaperone.\u00a0Acta Cryst<\/em>.\u00a0F62<\/strong>, 39-43.<\/p>\n

2005<\/strong><\/p>\n

Taylor AB, Stoj CS, Ziegler L, Kosman DJ, and Hart PJ.\u00a0 (2005).\u00a0 The copper-iron connection in biology: Structure of the metallo-oxidase Fet3p.\u00a0\u00a0Proc Natl Acad Sci.<\/em>\u00a0102<\/strong>, 15459-15464.\u00a0 PDB:\u00a01ZPU<\/a><\/p>\n

Di Noto L, Whitson LJ, Cao X, Hart PJ, and Levine RL.\u00a0 (2005).\u00a0 Proteasomal degradation of mutant superoxide dismutases linked to amyotrophic lateral sclerosis.\u00a0 J Biol Chem<\/em>.\u00a0280<\/strong>, 39907-39913.<\/p>\n

Jiang J, Prasad K, Lafer EM, and Sousa, R. (2005) Structural basis of interdomain communication in the Hsc70 chaperone. Mol Cell<\/em>. 20<\/strong>, 513-524.\u00a0 PDB:\u00a01YUW<\/a><\/p>\n

Whitson LJ and Hart PJ. (2005) \u201cCopper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis.\u201d in:\u00a0Metal Ions in Biological Systems. Vol 45 (Sigel, A., Sigel, H, and Sigel, R.O.K. eds) John Wiley & Sons Ltd., Chichester, UK.<\/p>\n

Hart PJ and Valentine JS. (2005).\u00a0 \u201cMetal-deficient copper-zinc superoxide dismutase and familial amyotrophic lateral sclerosis\u201d in\u00a0Medicinal Inorganic Chemistry.\u00a0 (Sessler, J.L., Doctrow, S.R., McMurray, T.S. and Lippard, S.J. eds).\u00a0 ACS Books, Washington D.C., U.S.A. pp. 348-365.<\/p>\n

Hart PJ, Nersissian AM, and DeBeer GS.\u00a0 (2005).\u00a0 \u201cCopper Proteins with Type I Sites\u201d in\u00a0Encyclopedia of Inorganic Chemistry, Vol. 2. (King, R.B., Atwood, D.A., Crabtree, R.H., Lukehart, C.M. and Scott, R.A. eds.) John Wiley & Sons, Ltd.\u00a0 Chichester, U.K.<\/p>\n

Hu G, Taylor AB, McAlister-Henn L, and Hart PJ. (2005). Crystallization and preliminary X-ray crystallographic analysis of yeast NAD+-specific isocitrate dehydrogenase.\u00a0Acta Crystallogr<\/em>. F61<\/strong>, 486-488.<\/p>\n

Antonyuk S, Elam JS, Hough MA, Strange RW, Doucette PA, Rodriguez, JA, Hayward LJ, Valentine JS, Hart PJ, and Hasnain SS. (2005).\u00a0 Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.\u00a0Protein Sci<\/em>.\u00a014<\/strong>, 1201-1213.<\/p>\n

2004<\/strong><\/p>\n

Doucette PA, Whitson LJ, Cao X, Schirf V, Demeler B, Valentine JS, Hansen JC, and Hart PJ.\u00a0 (2004).\u00a0 Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant: Insights into the molecular basis for dimer stability.\u00a0J Biol Chem<\/em>.\u00a0279<\/strong>, 54558-54566.<\/p>\n

Laliberte J, Whitson LJ, Beaudoin J, Holloway SP, Hart PJ, and Labbe S.\u00a0 (2004).\u00a0 The Schizosaccharomyces pombe Pccs protein functions in both copper trafficking and metal detoxification pathways.\u00a0\u00a0J Biol Chem<\/em>.\u00a0\u00a0279<\/strong>, 28744-28755.<\/p>\n

Hough MA, Grossmann JG, Antonyuk SV, Strange RW, Doucette PA, Rodriguez JA, Whitson LJ, Hart PJ, Hayward LJ, Valentine JS, and Hasnain SS. (2004).\u00a0 Dimer destabilization in superoxide dismutase may result in disease-causing properties: structures of motor neuron disease mutants.\u00a0Proc Natl Acad Sci. U.S.A<\/em>.\u00a0101<\/strong>, 5976-5981.<\/p>\n

2003<\/strong><\/p>\n

Elam JS, Taylor AB, Strange R, Antonyuk S, Doucette PA, Rodriguez JA, Hasnain SS, Hayward LJ, Valentine JS, Yeates TO, and Hart PJ. (2003).\u00a0 Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutants linked to familial ALS.\u00a0Nat Struct Biol<\/em>.\u00a010<\/strong>, 461-467.\u00a0 PDB:\u00a01OEZ<\/a>,\u00a01OZT<\/a>,\u00a01OZU<\/a><\/p>\n

Elam JS, Malek K, Rodriguez JA, Doucette PA, Taylor AB, Hayward LJ, Cabelli DE, Valentine JS, and Hart PJ. (2003).\u00a0 An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase.\u00a0\u00a0J Biol Chem<\/em>.\u00a0278<\/strong>, 21032-21039. PubMed PDB:\u00a01P1V<\/a><\/p>\n

Taylor AB, Benglis Jr, DM, Dhandayuthapani S, and Hart PJ. (2003).\u00a0 Structure of\u00a0Mycobacterium tuberculosis\u00a0methionine sulfoxide reductase A in complex with protein-bound methionine.\u00a0\u00a0J Bacteriol<\/em>.\u00a0185<\/strong>, 4119-4126.\u00a0 PDB:\u00a01NWA<\/a><\/p>\n

Jiang J, Taylor AB, Prasad K, Ishikawa-Brush Y, Hart PJ, Lafer EM, and Sousa R.\u00a0(2003). Structure-function analysis of the auxilin J-domain reveals an extended Hsc70 interaction interface.\u00a0Biochemistry<\/em>. 42<\/strong>, 5748-53. PDB:1NZ6<\/a><\/p>\n

Strange R, Antonyuk S, Hough MA, Doucette PA, Rodriguez JA, Hart PJ, Hayward LJ, Valentine JS, and Hasnain SS. (2003).\u00a0 The structure of holo and metal deficient wild type human Cu,Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis.\u00a0\u00a0J Mol Biol<\/em>.\u00a0328<\/strong>, 877-91.\u00a0 PDB:\u00a01HL4<\/a>,\u00a01HL5<\/a><\/p>\n

Valentine JS and Hart PJ. (2003).\u00a0 Misfolded CuZnSOD and ALS.\u00a0Proc Natl Acad Sci. U.S.A<\/em>.100<\/strong>, 3617-3622.<\/p>\n

2002<\/strong><\/p>\n

Hart PJ, Deep S, Taylor AB, Shu Z, Hinck CS, and Hinck AP.\u00a0 (2002). Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with TGF-beta3.\u00a0Nat Struct Biol<\/em>.\u00a09<\/strong>, 203-208.\u00a0 PDB:\u00a01KTZ<\/a><\/p>\n

Elam JS, Thomas ST, Holloway SP, Taylor AB, and Hart PJ. (2002). Copper Chaperones.\u00a0 In:\u00a0Advances in Protein Chemistry. (Valentine, J.S. and Gralla, E.B., eds.) Academic Press, San Diego, CA. pp. 151-219.<\/p>\n

Pascal JM, Hart PJ, Hecht NB, and Robertus JD. (2002). Crystal structure of TB-RBP, a novel RNA-binding and regulating protein.\u00a0\u00a0J Mol Biol<\/em>.\u00a0319<\/strong>, 1049-1057.\u00a0 PDB:\u00a01KEY<\/a><\/p>\n

2001<\/strong><\/p>\n

Nersissian AM, Hart PJ, and Valentine JS. (2001). Stellacyanin, a member of the phytocyanin family of plant proteins. In: Handbook of Metalloproteins (Messerschmidt, A., Huber, R., Poulos, T., and Wieghardt, K., eds) John Wiley and Sons, Ltd.,\u00a0 Chichester, England. pp. 1219-1234.<\/p>\n

2000<\/strong><\/p>\n

Hall LT, Sanchez RJ, Holloway SP, Zhu H, Stine JE, Lyons TJ, Demeler B, Schirf V, Hansen JC, Nersissian AM, Valentine JS, and Hart PJ. (2000). X-ray crystallographic and analytical ultracentrifugation analyses of truncated and full-length yeast copper chaperones for SOD (LYS7): a dimer-dimer model of LYS7-SOD association and copper delivery. Biochemistry<\/em>. 39<\/strong>, 3611-3623. PDB: 1EJ8<\/a><\/p>\n

Zhu H, Shipp E, Sanchez RJ, Liba A, Stine JE, Hart PJ, Gralla EB, Nersissian AM, and Valentine JS.\u00a0 (2000). Cobalt(2+) binding to human and tomato copper chaperone for superoxide dismutase: implications for the metal ion transfer mechanism. Biochemistry<\/em>. 39<\/strong>, 5413-5421.<\/p>\n

1999<\/strong><\/p>\n

Valentine JS, Hart PJ, and Gralla EB. (1999). \u201cCopper-zinc superoxide dismutase and ALS.\u201d In:\u00a0Advances in Experimental Medicine and Biology: Copper Transport and its Disorders:\u00a0 Molecular and Cellular Aspects\u00a0(Leone, A., and Mercer, J.F.B. eds.) Plenum Press, New York, New York. pp. 193-203.[\/vc_column_text][\/vc_column][vc_column width=”1\/3″]