Publications

2023

Tryptophan metabolites and anemia in patients with diabetic kidney disease. J Debnath S, Thomas N, Saliba A, Kottewar S, Grant S, Kasinath BS, Sharma K, Lorenzo C. Nephrol. 2023 May;36(4):1083-1085. doi: 10.1007/s40620-023-01620-0. Epub 2023 Apr 10. PMID: 37036660.

TGFβ instructs mTORC2 to activate PKCβII for increased TWIST1 expression in proximal tubular epithelial cell injury. Das, F., Ghosh-Choudhury, N., Maity, S., Kasinath, B.S. and Ghosh Choudhury, G. (2023), FEBS Lett, 597: 1300-1316. https://doi.org/10.1002/1873-3468.14599

Psychometric Properties of the Brief Fatigue Inventory in Hemodialysis Patients during a Dialysis Day: A Preliminary Report. Debnath S, Rueda R, Thomas N, Kottewar S, Grant S, Lorenzo C. Clin Nurs Res. 2023 Mar;32(3):445-451. doi: 10.1177/10547738221149811. Epub 2023 Jan 23. PMID: 36688335.

Empagliflozin in Patients with Chronic Kidney Disease. The EMPA-KIDNEY Collaborative Group; Herrington WG, Staplin N, Wanner C, Green JB, Hauske SJ, Emberson JR, Preiss D, Judge P, Mayne KJ, Ng SYA, Sammons E, Zhu D, Hill M, Stevens W, Wallendszus K, Brenner S, Cheung AK, Liu ZH, Li J, Hooi LS, Liu W, Kadowaki T, Nangaku M, Levin A, Cherney D, Maggioni AP, Pontremoli R, Deo R, Goto S, Rossello X, Tuttle KR, Steubl D, Petrini M, Massey D, Eilbracht J, Brueckmann M, Landray MJ, Baigent C, Haynes R. N Engl J Med. 2023 Jan 12;388(2):117-127. doi: 10.1056/NEJMoa2204233. Epub 2022 Nov 4. PMID: 36331190; PMCID: PMC7614055.

Empagliflozin reduces podocyte lipotoxicity in experimental Alport syndrome Ge, M., Molina, J., Kim, J.J., Mallela, S.K., Ahmad, A., Santos, J.V., Al-Ali, H., Mitrofanova, A., Sharma, K., Fontanesi, F. and Merscher, S., 2023.. Elife, 12, p.e83353.

Crabtree effect in kidney proximal tubule cells via late-stage glycolytic intermediates. Darshi, M., Tumova, J., Saliba, A., Kim, J., Baek, J., Pennathur, S. and Sharma, K., 2023. Iscience, 26(4).

Tryptophan metabolites and anemia in patients with diabetic kidney disease. Debnath, S., Thomas, N., Saliba, A., Kottewar, S., Grant, S., Kasinath, B.S., Sharma, K. and Lorenzo, C., 2023. Journal of Nephrology, pp.1-3.

Role of Kynurenine/Tryptophan Ratio in Kidney-Lung crosstalk in two porcine trauma-induced multi-organ injury models. Singh, P., Montemayor, D., Pamreddy, A., Drel, V., Ye, H., Franzone, A., Zang, Y., Roberts, T., Chung, K., Batchinsky, A. and Sharma, K., 2023. 332 Journal of Clinical and Translational Science, 7(s1), pp.99-99.

A generalized covariate-adjusted top-scoring pair algorithm with applications to diabetic kidney disease stage classification in the Chronic Renal Insufficiency Cohort (CRIC) Study. Kwan, B., Fuhrer, T., Montemayor, D., Fink, J.C., He, J., Hsu, C.Y., Messer, K., Nelson, R.G., Pu, M., Ricardo, A.C. and Rincon-Choles, H., 2023. BMC bioinformatics, 24(1), p.57.

Examining the Individual Response to a Low-Sodium Diet in Patients with Hypertension: Protocol for a Pilot Randomized Controlled Trial. Ko, J., Wang, J., Chung, M.L. and Sharma, K., 2023. JMIR Research Protocols, 12(1), p.e39058.

Exploration and analysis of R-loop mapping data with RLBase. Miller, H.E., Montemayor, D., Li, J., Levy, S.A., Pawar, R., Hartono, S., Sharma, K., Frost, B., Chedin, F. and Bishop, A.J., 2023. Nucleic acids research, 51(D1), pp.D1129-D1137.

Role of endogenous adenine in kidney failure and mortality with diabetes. Sharma, K., Zhang, G., Hansen, J., Bjornstad, P., Lee, H.J., Menon, R., Hejazi, L., Liu, J.J., Franzone, A., Looker, H.C. and Choi, B.Y., 2023. medRxiv, pp.2023-05.

2022

Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis. Das F, Ghosh-Choudhury N, Maity S, Kasinath BS, Choudhury GG. J Biol Chem. 2022 Sep;298(9):102246. doi: 10.1016/j.jbc.2022.102246. Epub 2022 Jul 11. PMID: 35835217; PMCID: PMC9399488.

Corrigendum to: Marmoset as a Model to Study Kidney Changes Associated With Aging. Lee HJ, Gonzalez O, Dick EJ, Donati A, Feliers D, Choudhury GG, Ross C, Venkatachalam M, Tardif SD, Kasinath BS. J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):84. doi: 10.1093/gerona/glab238. Erratum for: J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):315-324. PMID: 34542600; PMCID: PMC8915215.

Alkyl-substituted N-methylaryl-N’-aryl-4-aminobenzamides: A new series of small molecule inhibitors for Wip1 phosphatase. Robello M, Zheng H, Saha M, George Rosenker KM, Debnath S, Kumar JP, Tagad HD, Mazur SJ, Appella E, Appella DH. Eur J Med Chem. 2022 Dec 5;243:114763. doi: 10.1016/j.ejmech.2022.114763. Epub 2022 Sep 18. PMID: 36179402; PMCID: PMC9664485.

Transcriptional regulation by a RecQ helicase. Methods Enzymol. Debnath S, Lu X, Sharma S. 2022;673:227-249. doi: 10.1016/bs.mie.2022.03.057. Epub 2022 Apr 18. PMID: 35965009; PMCID: PMC9379128.

Genome-wide investigations on regulatory functions of RECQ1 helicase. Methods. Debnath S, Lu X, Lal A, Sharma S. 2022 Aug;204:263-268. doi: 10.1016/j.ymeth.2022.02.010. Epub 2022 Feb 26. PMID: 35231585; PMCID: PMC9233132.

Multi-scalar data integration links glomerular angiopoietin-tie signaling pathway activation with progression of diabetic kidney disease. Liu, J., Nair, V., Zhao, Y.Y., Chang, D.Y., Limonte, C., Bansal, N., Fermin, D., Eichinger, F., Tanner, E.C., Bellovich, K.A. and Steigerwalt, S., 2022. Diabetes, 71(12), pp.2664-2676.

Spatial N-glycomics with MALDI-MSI for human kidney tissue. D Velickovic, K Sharma, T Alexandrov, C Anderton. 202 DOI: dx.doi.org/10.17504/protocols.io.8epv5j1m4l1b/v2

Enhanced spatial mapping of histone proteoforms in human kidney through MALDI-MSI by high-field UHMR-orbitrap detection. Zemaitis, K.J., Veličković, D., Kew, W., Fort, K.L., Reinhardt-Szyba, M., Pamreddy, A., Ding, Y., Kaushik, D., Sharma, K., Makarov, A.A. and Zhou, M., 2022. Analytical chemistry, 94(37), pp.12604-12613.

A technology assisted precision ketogenic diet intervention for cardio-renal-metabolic health in overweight or obese adults: Protocol for a randomized controlled trial. Du, Y., Wang, J., Li, S., Dennis, B., Meireles, C., Siddiqui, N., Patel, D., Gelfond, J., Li, C., Alaeddini, A. and Drel, V., 2022. Contemporary Clinical Trials, 119, p.106845.

Quality-controlled R-loop meta-analysis reveals the characteristics of R-loop consensus regions. Miller, H.E., Montemayor, D., Abdul, J., Vines, A., Levy, S.A., Hartono, S.R., Sharma, K., Frost, B., Chédin, F. and Bishop, A.J., 2022. Nucleic acids research, 50(13), pp.7260-7286.

Controlled humidity levels for fine spatial detail information in enzyme-assisted N-glycan MALDI MSI. Velickovic, D., Sharma, K., Alexandrov, T., Hodgin, J.B. and Anderton, C.R., 2022. Journal of the American Society for Mass Spectrometry, 33(8), pp.1577-1580.

A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project. Butler, C.R., Appelbaum, P.S., Ascani, H., Aulisio, M., Campbell, C.E., de Boer, I.H., Dighe, A.L., Hall, D.E., Himmelfarb, J., Knight, R. and Mehl, K., 2022. American Journal of Kidney Diseases, 80(1), pp.132-138.

A reference tissue atlas for the human kidney. Hansen, J., Sealfon, R., Menon, R., Eadon, M.T., Lake, B.B., Steck, B., Anjani, K., Parikh, S., Sigdel, T.K., Zhang, G. and Velickovic, D., 2022. Science advances, 8(23), p.eabn4965.

Urinary proteomics identifies cathepsin D as a biomarker of rapid eGFR decline in type 1 diabetes. Limonte, C.P., Valo, E., Drel, V., Natarajan, L., Darshi, M., Forsblom, C., Henderson, C.M., Hoofnagle, A.N., Ju, W., Kretzler, M. and Montemayor, D., 2022. Diabetes care, 45(6), pp.1416-1427.

Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation. Menon, R., Bomback, A.S., Lake, B.B., Stutzke, C., Grewenow, S.M., Menez, S., D’Agati, V.D., Jain, S., Knight, R., Lecker, S.H. and Stillman, I., 2022. Kidney international, 101(6), pp.1116-1125.

Spatial metabolic profiling of Alzheimer disease and glioma. Walker, J., Pamreddy, A., Ghamasaee, P., Burket, A., Bieniek, K., Seshadri, S., Sharma, K. and Richardson, T., 2022, May. In JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (Vol. 81, No. 6, pp. 463-463). JOURNALS DEPT, 2001 EVANS RD, CARY, NC 27513 USA: OXFORD UNIV PRESS INC.

A review of extracorporeal blood purification techniques for the treatment of critically ill coronavirus disease 2019 patients. Niazi, N.S., Nassar, T.I., Stewart, I.J., Honore, P.M., Sharma, K. and Chung, K.K., 2022. Asaio Journal, 68(10), p.1219.

A multicenter evaluation of the seraph 100 microbind affinity blood filter for the treatment of severe COVID-19. Chitty, S.A., Mobbs, S., Rifkin, B.S., Stogner, S.W., Lewis, M.S., Betancourt, J., DellaVolpe, J., Abouzahr, F., Wilhelm, A.M., Szerlip, H.M. and Parikh, A., 2022. Critical Care Explorations, 4(4).

An adverse outcomes approach to study the effects of SARS-CoV-2 in 3D organoid models. Basu, A., Pamreddy, A., Singh, P. and Sharma, K., 2022. Journal of Molecular Biology, 434(3), p.167213.

Role of matrix assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI): A novel tool to study bioenergetic signature in kidney cancer. Garg, H., Pamreddy, A., Hejazi, L., Montemayor, D., Ding, Y., Venkatachalam, M.A., Sharma, K. and Kaushik, D., 2022, February. In EUROPEAN UROLOGY (Vol. 81, pp. S1654-S1655). RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS: ELSEVIER.

Empagliflozin reduces renal lipotoxicity in experimental Alport syndrome. Ge, M., Molina, J., Kim, J.J., Mallela, S.K., Ahmad, A., Varona Santos, J., Al-Ali, H., Mitrofanova, A., Sharma, K., Fontanesi, F. and Merscher, S., 2022. bioRxiv, pp.2022-10.

RLSuite: An integrative R-loop bioinformatics framework. Miller, H.E., Montemayor, D., Levy, S.A., Sharma, K., Frost, B. and Bishop, A.J., 2022. bioRxiv, pp.2022-07.

Cardiac Safety in Breast Cancer Patients Receiving Pegylated Liposome Doxorubicin Sequential Anti-HER2 Monoclonal Antibody Therapy. Huang, P., Huang, J.H., Zheng, Y.B., Cao, W.M., Shao, X.Y., Chen, J.Q., Huang, Y., Li, G.L., Sharma, K., Zhou, H.H. and Wang, X.J., 2022. Frontiers in Pharmacology, 13, p.883600.

High-throughput metabolomics and diabetic kidney disease progression: evidence from the chronic renal insufficiency (CRIC) study. Zhang, J., Fuhrer, T., Ye, H., Kwan, B., Montemayor, D., Tumova, J., Darshi, M., Afshinnia, F., Scialla, J.J., Anderson, A. and Porter, A.C., 2022. American journal of nephrology, 53(2-3), pp.215-225.

2021

Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury. Lee, H. J., Mariappan, M. M., Norton, L., Bakewell, T., Feliers, D., Oh, S. B., Donati, A., Rubannelsonkumar, C. S., Venkatachalam, M. A., Harris, S. E., Rubera, I., Tauc, M., Ghosh Choudhury, G., Kahn, C. R., Sharma, K., DeFronzo, R. A., & Kasinath, B. S. (2021). JCI insight, 6(3), e143619.

“A Multimodal and Integrated Approach to Interrogate Human Kidney Biopsies with Rigor and Reproducibility: Guidelines from the Kidney Precision Medicine Project.” El-Achkar, Tarek M., Michael T. Eadon, Rajasree Menon, Blue B. Lake, Tara K. Sigdel, Theodore Alexandrov, Samir Parikh, Guanshi Zhang, Dejan Dobi, Kenneth W. Dunn, Edgar A. Otto, Christopher R. Anderton, Jonas M. Carson, Jinghui Luo, Chris Park, Habib Hamidi, Jian Zhou, Paul Hoover, Andrew Schroeder, Marianinha Joanes, Evren U. Azeloglu, Rachel Sealfon, Seth Winfree, Becky Steck, Yongqun He, Vivette D’Agati, Ravi Iyengar, Olga G. Troyanskaya, Laura Barisoni, Joseph Gaut, Kun Zhang, Zoltan Laszik, Brad H. Rovin, Pierre C. Dagher, Kumar Sharma, Minnie M. Sarwal, Jeffrey B. Hodgin, Charles E. Alpers, Matthias Kretzler, and Sanjay Jain. Physiological Genomics 53.1 (2021): 1-11.

2020

Temporal Telomere and DNA Damage Responses in the Space Radiation Environment. Jared J. Luxton, Miles J. McKenna, Lynn E. Taylor, Kerry A. George, Sara R. Zwart, Brian E. Crucian, Viktor R. Drel, Francine E. Garrett-Bakelman, Matthew J. Mackay, Daniel Butler, Jonathan Foox, Kirill Grigorev, Daniela Bezdan, Cem Meydan, Scott M. Smith, Kumar Sharma, Christopher E. Mason, Susan M. Bailey. Cell Reports, Volume 33, Issue 10, 2020, 108435, ISSN 2211-1247.

A Targeted Multiomics Approach to Identify Biomarkers Associated with Rapid eGFR Decline in Type 1 Diabetes. Limonte, C. P., Valo, E., Montemayor, D., Afshinnia, F., Ahluwalia, T. S., Costacou, T., Darshi, M., Forsblom, C., Hoofnagle, A. N., Groop, P. H., Miller, R. G., Orchard, T. J., Pennathur, S., Rossing, P., Sandholm, N., Snell-Bergeon, J. K., Ye, H., Zhang, J., Natarajan, L., de Boer, I. H., … Sharma, K. (2020). American journal of nephrology, 51(10), 839–848.

Gut Microbial Changes in Diabetic db/db Mice and Recovery of Microbial Diversity upon Pirfenidone Treatment. Singh, H., Miyamoto, S., Darshi, M., Torralba, M. G., Kwon, K., Sharma, K., & Pieper, R. (2020). Microorganisms, 8(9), 1347.

Storage Conditions of Human Kidney Tissue Sections Affect Spatial Lipidomics Analysis Reproducibility. Jessica K. Lukowski, Annapurna Pamreddy, Dusan Velickovic, Guanshi Zhang, Ljiljana Pasa-Tolic, Theodore Alexandrov, Kumar Sharma, Christopher R. Anderton. Journal of the American Society for Mass Spectrometry 2020 31 (12), 2538-2546. DOI: 10.1021/jasms.0c00256

A role for tubular Na+/H+ exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin. Onishi, A., Fu, Y., Patel, R., Darshi, M., Crespo-Masip, M., Huang, W., Song, P., Freeman, B., Kim, Y. C., Soleimani, M., Sharma, K., Thomson, S. C., & Vallon, V. (2020). American journal of physiology. Renal physiology, 319(4), F712–F728.

Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis. Kawanishi, K., Saha, S., Diaz, S., Vaill, M., Sasmal, A., Siddiqui, S. S., Choudhury, B., Sharma, K., Chen, X., Schoenhofen, I. C., Sato, C., Kitajima, K., Freeze, H. H., Münster-Kühnel, A., & Varki, A. (2021). The Journal of clinical investigation, 131(5), e137681.

Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity. Neeharika Nemani, Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, Karthik Ramachandran, Benjamin T. Enslow, Cherubina S. Rubannelsonkumar, Santhanam Shanmughapriya, Varshini Mallireddigari, Soumya Maity, Pragya Singhmalla, Kalimuthusamy Natarajanseenivasan, Robert Hooper, Christopher E. Shannon, Warren G. Tourtellotte, Brij B. Singh, W. Brian Reeves, Kumar Sharma, Luke Norton, Subramanya Srikantan, Jonathan Soboloff, Muniswamy Madesh. Science Signaling21 Apr 2020.

Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease. Farsad Afshinnia, Lixia Zeng, Jaeman Byun, Stefanie Wernisch, Rajat Deo, Jing Chen, Lee Hamm, Edgar R Miller, Eugene P Rhee, Michael J Fischer, Kumar Sharma, Harold I Feldman, George Michailidis, Subramaniam Pennathur, the CRIC Study Investigators, Nephrology Dialysis Transplantation, Volume 35, Issue 2, February 2020, Pages 303312.

Metabolomic Markers of Kidney Function Decline in Patients With Diabetes: Evidence From the Chronic Renal Insufficiency Cohort (CRIC) Study. Brian Kwan, Tobias Fuhrer, Jing Zhang, Manjula Darshi, Benjamin Van Espen, Daniel Montemayor, Ian H. de Boer, Mirela Dobre, Chi-yuan Hsu, Tanika N. Kelly, Dominic S. Raj, Panduranga S. Rao, Santosh L. Saraf, Julia Scialla, Sushrut S. Waikar, Kumar Sharma, Loki Natarajan, Lawrence J. Appel, Harold I. Feldman, Alan S. Go, Jiang He, James P. Lash, Mahboob Rahman, Raymond R. Townsend. American Journal of Kidney Diseases, Volume 76, Issue 4, 2020, Pages 511-520, ISSN 0272-6386.

DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules. Zhang, G., Zhang, J., DeHoog, R.J. et al. Metabolomics 16, 11 (2020).

Branched-Chain Amino Acids Depletion during Hemodialysis Is Associated with Fatigue. Debnath S., Lorenzo C., Bansal S., Morales J., Rueda R.O., Kasinath B.S., Sharma K., O’Connor J.C. Am J Nephrol 2020; 51: 565 – 571.

Assessment of fatigue in hemodialysis patients: Performance of the Brief Fatigue Inventory. Debnath, S., Rueda, R., Bansal, S., Sharma, K., & Lorenzo, C. (2021). General hospital psychiatry, 68, 115–117.

Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes. Jennifer Concepcion, Katherine Chen, Rintaro Saito, Jon Gangoiti, Eric Mendez, Maria Eleni Nikita, Bruce A. Barshop, Loki Natarajan, Kumar Sharma, Jane J. Kim. PLoS One, June 2020. DOI 10.1371/journal.pone.0234970

Comparative genomics and diversity of SARS-CoV-2 suggest potential regional virulence. Sundru Manjulata Devi, Annapurna Pamreddy, Balakuntalam Kasinath, Kumar Sharma. Research Square. 2020. DOI: https://doi.org/10.21203/rs.3.rs-29557/v1

mGWAS: next generation genetic prediction in kidney disease. Montemayor, D., Sharma, K. Nat Rev Nephrol 16, 255–256 (2020). https://doi.org/10.1038/s41581-020-0270-0

Towards Building a Smart Kidney Atlas: Network-based integration of multimodal transcriptomic, proteomic, metabolomic and imaging data in the Kidney Precision Medicine Project. Jens Hansen, Rachel Sealfon, Rajasree Menon, Michael T. Eadon, Blue. Lake, BeckySteck, Dejan Dobi, Samir Parikh, Tara.K. Sidgel, Theodore Alexandrov, AndrewSchroeder, Edgar A. Otto, Christopher R. Anderton, Daria Barwinska, Guanshi Zheng, Michael P. Rose, John P. Shapiro, Dusan Velickovic, Annapurna Pamreddy, SethWinfree, Yongqun He, Ian H. deBoer, JeffreyHodgin, Abhijit Nair, Kumar Sharma, Minnie Sarwal, Kun Zhang, Jonathan Himmelfarb, Zoltan Laszik, Brad Rovin, Pierre C.Dagher, John Cijiang He, Tarek M. El-Achkar, Sanjay Jain, Olga G. Troyanskaya, Matthias Kretzler, Ravi Iyengar, Evren U. Azeloglu, for the Kidney Precision Medicine Project Consortium bioRxiv 2020.07.23.216507; doi: https://doi.org/10.1101/2020.07.23.216507

Nephrology Training: Time to Revisit Integrative Physiology. Bansal, S., Kanakia, R., Sharma, K., Tsai, S., & Prasad, A. (2020). American journal of nephrology, 51(3), 244–248. https://doi.org/10.1159/000505994

“Predictive Biomarkers in Nephrology Around the Corner.” Perco, Paul, and Kumar Sharma. Kidney international reportsvol. 5,1 1-3. 2 Nov. 2019, doi:10.1016/j.ekir.2019.10.009

2019

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight. Francine E. Garrett-Bakelman, Manjula Darshi, Stefan J. Green, Ruben C. Gur, Ling Lin, Brandon R. Macias, Miles J. Mckenna, Cem Meydan, Tejaswini Mishra, Jad Nasrini, Brian D. Piening, Lindsay F. Rizzardi, Kumar Sharma, Jamila H. Siamwala, Lynn Taylor, Martha Hotz Vitaterna, Maryam Afkarian, Ebrahim Afshinnekoo, Sara Ahadi, Aditya Ambati, Maneesh Arya, Daniela Bezdan, Colin M. Callahan, Songjie Chen, Augustine M. K. Choi, George E. Chlipala, Kévin Contrepois, Marisa Covington, Brian E. Crucian, Immaculata De Vivo, David F. Dinges, Douglas J. Ebert, Jason I. Feinberg, Jorge A. Gandara, Kerry A. George, John Goutsias, George S. Grills, Alan R. Hargens, Martina Heer, Ryan P. Hillary, Andrew N. Hoofnagle, Vivian Y. H. Hook, Garrett Jenkinson, Peng Jiang, Ali Keshavarzian, Steven S. Laurie, Brittany Lee-Mcmullen, Sarah B. Lumpkins, Matthew Mackay, Mark G. Maienschein-Cline, Ari M. Melnick, Tyler M. Moore, Kiichi Nakahira, Hemal H. Patel, Robert Pietrzyk, Varsha Rao, Rintaro Saito, Denis N. Salins, Jan M. Schilling, Dorothy D. Sears, Caroline K. Sheridan, Michael B. Stenger, Rakel Tryggvadottir, Alexander E. Urban, Tomas Vaisar, Benjamin Van Espen, Jing Zhang, Michael G. Ziegler, Sara R. Zwart, John B. Charles, Craig E. Kundrot, Graham B. I. Scott, Susan M. Bailey, Mathias Basner, Andrew P. Feinberg, Stuart M. C. Lee, Christopher E. Mason, Emmanuel Mignot, Brinda K. Rana, Scott M. Smith, Michael P. Snyder, Fred W. Turek Science12 Apr 2019

AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice. Declèves, A. E., Mathew, A. V., Armando, A. M., Han, X., Dennis, E. A., Quehenberger, O., & Sharma, K. (2019). Journal of lipid research, 60(5), 937–952. https://doi.org/10.1194/jlr.M088690

Association of Urinary Oxalate Excretion With the Risk of Chronic Kidney Disease Progression. Sushrut S. Waikar, MD, MPH1; Anand Srivastava, MD, MPH2; Ragnar Palsson, MD1; Tariq Shafi, MBBS, MHS3; Chi-yuan Hsu, MD, MSc4; Kumar Sharma, MD5; James P. Lash, MD6; Jing Chen, MD, MMSc, MSc7,8; Jiang He, MD, PhD7,8; John Lieske, MD9; Dawei Xie, PhD10,11; Xiaoming Zhang, MS10,11; Harold I. Feldman, MD, MSCE10,11; Gary C. Curhan, MD, ScD1. JAMA Internal Medicine. March 4, 2019. doi:10.1001/jamainternmed.2018.7980

Effect of renal tubule-specific knockdown of the Na+/H+ exchanger NHE3 in Akita diabetic mice. Akira Onishi, Yiling Fu, Manjula Darshi, Maria Crespo-Masip, Winnie Huang, Panai Song, Rohit Patel, Young Chul Kim, Josselin Nespoux, Brent Freeman, Manoocher Soleimani, Scott Thomson, Kumar Sharma, and Volker Vallon. American Journal of Physiology-Renal Physiology 2019 317:2, F419-F434

Blockade of MCU-Mediated Ca2+ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation. Dhanendra Tomar, Fabián Jaña, Zhiwei Dong, William J. Quinn, Pooja Jadiya, Sarah L. Breves, Cassidy C. Daw, Subramanya Srikantan, Santhanam Shanmughapriya, Neeharika Nemani, Edmund Carvalho, Aparna Tripathi, Alison M. Worth, Xueqian Zhang, Roshanak Razmpour, Ajay Seelam, Stephen Rhode, Anuj V. Mehta, Michael Murray, Daniel Slade, Servio H. Ramirez, Prashant Mishra, Glenn S. Gerhard, Jeffrey Caplan, Luke Norton, Kumar Sharma, Sudarsan Rajan, Darius Balciunas, Dayanjan S. Wijesinghe, Rexford S. Ahima, Joseph A. Baur, Muniswamy Madesh. Cell Reports, Volume 26, Issue 13, 2019, Pages 3709-3725.e7, ISSN 2211-1247.

METASPACE: A community-populated knowledge base of spatial metabolomes in health and disease. Theodore Alexandrov, Katja Ovchinnikova, Andrew Palmer, Vitaly Kovalev, ArtemTarasov, Lachlan Stuart, Renat Nigmetzianov, Dominik Fay, Key METASPACE contributors, Mathieu Gaudin, Cristina Gonzalez Lopez, Marina Vetter, John Swales, Mark Bokhart, Mario Kompauer, James McKenzie, Luca Rappez, Dusan Velickovic, Regis Lavigne, Guanshi Zhang, Dinaiz Thinagaran, Elisa Ruhland, Marta Sans, SergioTriana, Denis Abu Sammour, Sarah Aboulmagd, Charlotte Bagger, Nicole Strittmatter, Angelos Rigopoulos, Erin Gemperline, Asta Maria Joensen, Benedikt Geier, ChristineQuiason, Eric Weaver, Mridula Prasad, Benjamin Balluff, Konstantin Nagornov, LingjunLi, Michael Linscheid, Carsten Hopf, Dimitri Heintz, Manuel Liebeke, BernhardSpengler, Berin Boughton, Christian Janfelt, Kumar Sharma, Charles Pineau, Christopher Anderton, Shane Ellis, Michael Becker, József Pánczél, Georges DaViolante, David Muddiman, Richard Goodwin, Livia Eberlin, Zoltan Takats, SheerinShahidi-Latham. bioRxiv 539478; doi: https://doi.org/10.1101/539478

Increased lipogenesis and impaired β-oxidation predict type 2 diabetic kidney disease progression in American Indians. Afshinnia, F., Nair, V., Lin, J., Rajendiran, T. M., Soni, T., Byun, J., Sharma, K., Fort, P. E., Gardner, T. W., Looker, H. C., Nelson, R. G., Brosius, F. C., Feldman, E. L., Michailidis, G., Kretzler, M., & Pennathur, S. (2019). JCI insight, 4(21), e130317. https://doi.org/10.1172/jci.insight.130317

Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis. Marius A. Øvrehus, Per Bruheim, Wenjun Ju, Leila R. Zelnick, Knut A. Langlo, Kumar Sharma, Ian H. de Boer, Stein I. Hallan. Kidney International Reports, Volume 4, Issue 2, 2019, Pages 321-333, ISSN 2468-0249.

Molecular Imaging of the Glomerulus via Mesangial Cell Uptake of Radiolabeled Tilmanocept. Zhengtao Qin, Carl K. Hoh, Emilia S. Olson, Amin Haghighat Jahromi, David J. Hall, Christopher V. Barback, Young-Hyun You, Motoko Yanagita, Kumar Sharma and David R. Vera. Journal of Nuclear Medicine September 2019, 60 (9) 1325-1332; DOI: https://doi.org/10.2967/jnumed.118.223727

Global Health Training Opportunities in North American Nephrology Fellowships. Robert Rope, Jeffrey Perl and Shuchi Anand; on behalf of the International Society of Nephrology North American and Caribbean Regional Board. Kidney Int Rep (2019) 4, 904–907; https://doi.org/10.1016/j.ekir.2019.04.019.

SAT-LB048 Identification of Pathognomonic Purine Synthesis Biomarkers by Metabolomic Profiling of Youth with Type 2 Diabetes. Jennifer Concepcion, MD, Katherine Chen, BSc, Rin Saito, PhD, Eric Mendez, MD, Jon Gangoiti, MS, Bruce Barshop, MD, PhD, Loki Natarajan, PhD, Kumar Sharma, MD, Jane Kim, MD. Journal of the Endocrine Society, Volume 3, Issue Supplement_1, April-May 2019, SAT–LB048, https://doi.org/10.1210/js.2019-SAT-LB048

Chapter 12 – Role of Mitochondria in the Regulation of Kidney Function and Metabolism in Type 2 Diabetes. Xianlin Han, Yuguang Shi, Maggie Diamond-Stanic, Kumar Sharma. Editor(s): Béatrice Morio, Luc Pénicaud, Michel Rigoulet. Mitochondria in Obesity and Type 2 Diabetes. Academic Press, 2019, Pages 287-300, ISBN 9780128117521.

Management of calciphylaxis in a burn center: A case series and review of the literature.Dado DN , Huang B, Foster DV, Nielsen JS, Gurney JM, Morrow BD, Sharma K, Chung KK, Ainsworth CR. Burns. 2019 Feb;45(1):241-246. PMID: 30322738

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K. J Mol Cell Cardiol. 2019 Feb;127:232-245. PMID: 30611795

Impaired non-homologous end joining in human primary alveolar type II cells in emphysema. Kosmider B, Lin CR, Vlasenko L, Marchetti N, Bolla S, Criner GJ, Messier E, Reisdorph N, Powell RL, Madesh M, Kelsen S, Xander N, Correll KA, Mason RJ, Bahmed K. Sci Rep. 2019 Jan 29;9(1):920. PMID: 30696938

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury. Woods JJ, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan SR, Thomas M, Carvalho E, Ramachandran K, Srikantan S, Stathopulos PB, Wilson JJ, Madesh M. ACS Cent Sci. 2019 Jan 23;5(1):153-166. PMID: 30693334

Myofibroblasts acquire retinoic acid-producing ability during fibroblast-to-myofibroblast transition following kidney injury. Nakamura J, Sato Y, Kitai Y, Wajima S, Yamamoto S, Oguchi A, Yamada R, Kaneko K, Kondo M, Uchino E, Tsuchida J, Hirano K, Sharma K, Kohno K, Yanagita M. Kidney Int. 2019 Jan 16. pii: S0085-2538(18)30806-8. PMID: 30661714

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. J Cell Physiol. 2019 Jan 13. PMID: 30637731

Sex-Related Disparities in CKD Progression. Ricardo AC, Yang W, Sha D, Appel LJ, Chen J, Krousel-Wood M, Manoharan A, Steigerwalt S, Wright J, Rahman M, Rosas SE, Saunders M, Sharma K, Daviglus ML, Lash JP; CRIC Investigators. J Am Soc Nephrol. 2019 Jan;30(1):137-146. PMID: 30510134

2018

Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial. de Zeeuw D, Renfurm RW, Bakris G, Rossing P, Perkovic V, Hou FF, Nangaku M, Sharma K, Heerspink HJL, Garcia-Hernandez A, Larsson TE. Lancet Diabetes Endocrinol. 2018 Dec;6(12):925-933. PMID: 30413396

Self-reported Intentional Weight Loss and Risk of Death in Moderate Chronic Kidney Disease in the United States. Bansal S, Wei G, Boucher RE, Beddhu S. J Ren Nutr. 2018 Nov;28(6):422-427. PMID: 30077396

Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM. JAMA Cardiol. 2018 Oct 1;3(10):929-938. PMID: 30140897

The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation. Hirschler-Laszkiewicz I, Chen SJ, Bao L, Wang J, Zhang XQ, Shanmughapriya S, Keefer K, Madesh M, Cheung JY, Miller BA. Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C571-C586. PMID: 30020827

Methylene Blue Counteracts H₂S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction. Cheung JY, Wang J, Zhang XQ, Song J, Davidyock JM, Prado FJ, Shanmughapriya S, Worth AM, Madesh M, Judenherc-Haouzi A, Haouzi P. Cardiovasc Toxicol. 2018 Oct;18(5):407-419. PMID: 29603116

Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. Myers VD, Tomar D, Madesh M, Wang J, Song J, Zhang XQ, Gupta MK, Tahrir FG, Gordon J, McClung JM, Kontos CD, Khalili K, Cheung JY, Feldman AM. J Cell Physiol. 2018 Sep; 233(9):6319-6326. PMID: 29323723

Molecular regulation of MCU: Implications in physiology and disease. Nemani N, Shanmughapriya S, Madesh M. Cell Calcium. 2018 Sep; 74:86-93. Review. PMID: 29980025

A new drug combination significantly reduces kidney tumor progression in kidney mouse model. Liang S, Cuellar T, Nowacki M, Nayak BK, Dong L, Li B, Sharma K, Habib SL. Oncotarget. 2018 Aug 31;9(68):3PMID: 30250638 2900-32916.

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation. Shanmughapriya S, Tomar D, Dong Z, Slovik KJ, Nemani N, Natarajaseenivasan K, Carvalho E, Lu C, Corrigan K, Garikipati VNS, Ibetti J, Rajan S, Barrero C, Chuprun K, Kishore R, Merali S, Tian Y, Yang W, Madesh M. Nat Commun. 2018 Aug 29;9(1):3449. PMID: 30158529

Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease. Afshinnia F, Zeng L, Byun J, Wernisch S, Deo R, Chen J, Hamm L, Miller ER, Rhee EP, Fischer MJ, Sharma K, Feldman HI, Michailidis G, Pennathur S; CRIC Study Investigators. Nephrol Dial Transplant. 2018 Jul 25. PMID: 30137494

Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies. Sharma K, Paša-Tolić L. Kidney Int. 2018 Jun;93(6):1265-1267. PMID: 29792268

The Warburg Effect in Diabetic Kidney Disease. Zhang G, Darshi M, Sharma K. Semin Nephrol. 2018 Mar;38(2):111-120. PMID: 29602394.

Introduction: Systems Biology of Kidney Disease. Sharma K, Susztak K, Pennathur S. Semin Nephrol. 2018 Mar;38(2):99-100. PMID: 29602402.

Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus. Yamamoto CM, Murakami T, Oakes ML, Mitsuhashi M, Kelly C, Henry RR, Sharma K. Am J Nephrol. 2018 May 18;47(5):283-291. PMID: 29779026.

Urine Metabolites are associated with glomerular lesions in type 2 diabetes. Saulnier P-J, Darshi M, Wheelock KM, Looker HC, Fufaa, GD, Knowler WC, Weil EJ, Tanamas SK, Lemley KV, Saito R, Natarajan L, Nelson RG, and Sharma K. Metabolomics. 2018 14:84.

2017

A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression. Zhang G, Saito R, Sharma K. Kidney Int. 2017 Jun;91(6):1274-1276. PMID: 28501300.
Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients. Hallan S, Afkarian M, Zelnick LR, Kestenbaum B, Sharma S, Saito R, Darshi M, Barding G, Raftery D, Ju W, Kretzler M, Sharma K, de Boer IH. EBioMedicine. 2017 Dec;26:68-77. PMID: 29128444.
AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin. Börgeson E, Wallenius V, Syed GH, Darshi M, Lantero Rodriguez J, Biörserud C, Ragnmark Ek M, Björklund P, Quiding-Järbrink M, Fändriks L, Godson C, Sharma K. Diabetologia. 2017 Apr;60(4):729-739. PMID: 28188334.
Mitochondrial Dysfunction in the Diabetic Kidney. Sharma K. Adv Exp Med Biol. 2017;982:553-562. PMID: 28551806.
Myeloperoxidase Activity and Oxidized Amino Acids as Biomarkers in Chronic Kidney Disease and Coronary Artery Disease. Sharma K. Am J Nephrol. 2017. PMID: 28715823.
Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINA-T2D trial. Groop PH, Cooper ME, Perkovic V, Hocher B, Kanasaki K, Haneda M, Schernthaner G, Sharma K, Stanton RC, Toto R, Cescutti J, Gordat M, Meinicke T, Koitka-Weber A, Thiemann S, von Eynatten M. Diabetes Obes Metab. 2017 Nov;19(11):1610-1619. PMID: 28636754.
Acid Load and Phosphorus Homeostasis in CKD. Khairallah P, Isakova T, Asplin J, Hamm L, Dobre M, Rahman M, Sharma K, Leonard M, Miller E 3rd, Jaar B, Brecklin C, Yang W, Wang X, Feldman H, Wolf M, Scialla JJ; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators..Am J Kidney Dis. 2017 Oct;70(4):541-550. PMID: 28645705.

2016

Systems biology analysis reveals role of MDM2 in diabetic nephropathy. Saito R, Rocanin-Arjo A, You YH, Darshi M, Van Espen B, Miyamoto S, Pham J, Pu M, Romoli S, Natarajan L, Ju W, Kretzler M, Nelson R, Ono K, Thomasova D, Mulay SR, Ideker T, D’Agati V, Beyret E, Belmonte JC, Anders HJ, Sharma K. JCI Insight. 2016 Oct 20;1(17):e87877. PMID: 27777973.
Mass Spectrometry Imaging Reveals Elevated Glomerular ATP/AMP in Diabetes/obesity and Identifies Sphingomyelin as a Possible Mediator. Miyamoto S, Hsu CC, Hamm G, Darshi M, Diamond-Stanic M, Declèves AE, Slater L, Pennathur S, Stauber J, Dorrestein PC, Sharma K. EBioMedicine. 2016 May;7:121-34. PMID: 27322466.
Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease. You YH, Quach T, Saito R, Pham J, Sharma K. J Am Soc Nephrol. 2016 Feb;27(2):466-81. PMID: 26203118.
Tissue-specific metabolic reprogramming drives nutrient flux in diabetic complications.Sas KM, Kayampilly P, Byun J, Nair V, Hinder LM, Hur J, Zhang H, Lin C, Qi NR, Michailidis G, Groop PH, Nelson RG, Darshi M, Sharma K, Schelling JR, Sedor JR, Pop-Busui R, Weinberg JM, Soleimanpour SA, Abcouwer SF, Gardner TW, Burant CF, Feldman EL, Kretzler M, Brosius FC 3rd, Pennathur S. JCI Insight. 2016 Sep 22;1(15):e86976. PMID: 27699244.
Metabolomics in Diabetic Kidney Disease: Unraveling the Biochemistry of a Silent Killer. Darshi M, Van Espen B, Sharma K. Am J Nephrol. 2016;44(2):92-103. PMID: 27410520.
Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease. Coughlan MT, Sharma K. Kidney Int. 2016 Aug;90(2):272-279. PMID: 27217197.
The Role of Mitochondria in Diabetic Kidney Disease. Hallan S, Sharma K. Curr Diab Rep. 2016 Jul;16(7):61. PMID: 27155611.
Obesity and Diabetic Kidney Disease: Role of Oxidant Stress and Redox Balance. Sharma K. Antioxid Redox Signal. 2016 Aug 1;25(4):208-16. PMID: 26983586.
Resveratrol inhibits renal interstitial fibrosis in diabetic nephropathy by regulating AMPK/NOX4/ROS pathway. He T, Xiong J, Nie L, Yu Y, Guan X, Xu X, Xiao T, Yang K, Liu L, Zhang D, Huang Y, Zhang J, Wang J, Sharma K, Zhao J. J Mol Med (Berl). 2016 Dec;94(12):1359-1371. PMID: 27488452.

2015

Severity and Frequency of Proximal Tubule Injury Determines Renal Prognosis. Takaori K, Nakamura J, Yamamoto S, Nakata H, Sato Y, Takase M, Nameta M, Yamamoto T, Economides AN, Kohno K, Haga H, Sharma K, Yanagita M. J Am Soc Nephrol. 2015 Dec 23. [Epub ahead of print]
Treatment-Induced Changes in Plasma Adiponectin Do Not Reduce Urinary Albumin Excretion in the Diabetes Prevention Program Cohort. Mather KJ, Pan Q, Knowler WC, Funahashi T, Bray GA, Arakaki R, Falkner B, Sharma K, Goldstein BJ; DPP Research Group, PLoS One. 2015 10(8):e0136853.
Dipeptidyl peptidase-4 inhibition with linagliptin and effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: Rationale and design of the MARLINA-T2D™ trial. Groop PH, Cooper ME, Perkovic V, Sharma K, Schernthaner G, Haneda M, Hocher B, Gordat M, Cescutti J, Woerle HJ, von Eynatten M, Diab Vasc Dis Res. 2015 12(6):455-62.
Interactions between HIF-1α and AMPK in the regulation of cellular hypoxia adaptation in chronic kidney disease. Li H, Satriano J, Thomas JL, Miyamoto S, Sharma K, Pastor-Soler NM, Hallows KR, Singh P. Am J Physiol Renal Physiol. 2015 309(5):F414-28
Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease. Börgeson E, Johnson AM, Lee YS, Till A, Syed GH, Ali-Shah ST, Guiry PJ, Dalli J, Colas RA, Serhan CN, Sharma K, Godson C. Cell Metab. 2015 22(1):125-37.
Obstructive Sleep Apnea and Kidney Disease: A Potential Bidirectional Relationship? Abuyassin B, Sharma K, Ayas NT, Laher I. J Clin Sleep Med. 2015 11(8):915-24.
NADPH oxidase NOX1 is involved in activation of protein kinase C and premature senescence in early stage diabetic kidney. Zhu K, Kakehi T, Matsumoto M, Iwata K, Ibi M, Ohshima Y, Zhang J, Liu J, Wen X, Taye A, Fan C, Katsuyama M, Sharma K, Yabe-Nishimura C. Free Radic Biol Med. 2015 83:21-30.
Beneficial Effects of AMP-Activated Protein Kinase Agonists in Kidney Ischemia-Reperfusion: Autophagy and Cellular Stress Markers. Declèves AE, Sharma K, Satriano J. Nephron Exp Nephrol. 2014 Dec 6.
Obesity and kidney disease: differential effects of obesity on adipose tissue and kidney inflammation and fibrosis. Declèves AE, Sharma K. Curr Opin Nephrol Hypertens. 2015 24(1):28-36.
AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys. Zhao J, Miyamoto S, You YH, Sharma K. Am J Physiol Renal Physiol. 2015 308(10):F1167-77.
Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development. Kang HM, Ahn SH, Choi P, Ko YA, Han SH, Chinga F, Park AS, Tao J, Sharma K, Pullman J, Bottinger EP, Goldberg IJ, Susztak K. Nat Med. 2015 21(1):37-46.

2014

Regulation of lipid accumulation by AMP-activated kinase [corrected] in high fat diet-induced kidney injury.Declèves AE, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP, Nortier JL, Farquhar MG, Naviaux RK, Sharma K. Kidney Int. 2014 Mar;85(3):611-23. doi: 10.1038/ki.2013.462. Epub 2013 Dec 4.
Novel targets of antifibrotic and anti-inflammatory treatment in CKD. Declèves AE, Sharma K. Nat Rev Nephrol. 2014 May;10(5):257-67. doi: 10.1038/nrneph.2014.31. Epub 2014 Mar 25.
Tribbles Homolog 3 Attenuates Mammalian Target of Rapamycin Complex-2 Signaling and Inflammation in the Diabetic Kidney. Borsting E, Patel SV, Declèves AE, Lee SJ, Rahman QM, Akira S, Satriano J, Sharma K, Vallon V, Cunard R. J Am Soc Nephrol. 2014 Mar 27. [Epub ahead of print]
Tell-Tale Signs of Perturbed Podocytes. Sharma K. J Am Soc Nephrol. 2014 Mar 27. [Epub ahead of print]
Adiponectin effects on the kidney. Sweiss N, Sharma K. Best Pract Res Clin Endocrinol Metab. 2014 Jan;28(1):71-9. Epub 2013 Sep 5.

2013

Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Vallon V, Rose M, Gerasimova M, Satriano J, Platt KA, Koepsell H, Cunard R, Sharma K, Thomson SC, Rieg T. Kidney Int. 2013 Jan 15;304(2):F156-67. Epub 2012 Nov 14.
Role of Nox2 in diabetic kidney disease. You YH, Okada S, Ly S, Jandeleit-Dahm K, Barit D, Namikoshi T, Sharma K. 2013 Apr 1;304(7):F840-8. Epub 2013 Feb 6.
Obesity, immunomodulation and chronic kidney disease. Börgeson E, Sharma K. 2013 Aug;13(4):618-24. Epub 2013 Jun 7.
Induction of AMPK activity corrects early pathophysiological alterations in the subtotal nephrectomy model of chronic kidney disease. Satriano J, Sharma K, Blantz RC, Deng A. 2013 Sep 1;305(5):F727-33. Epub 2013 Jul 3.
Autophagy and metabolic changes in obesity-related chronic kidney disease. Satriano J, Sharma K. 2013 Nov;28 Suppl 4:iv29-36. Epub 2013 Jul 30.
Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging. Declèves AE, Rychak JJ, Smith DJ, Sharma K. 2013 Nov 1;305(9):F1343-51. Epub 2013 Sep 18.
Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. Sharma K, Karl B, Mathew AV, Gangoiti JA, Wassel CL, Saito R, Pu M, Sharma S, You YH, Wang L, Diamond-Stanic M, Lindenmeyer MT, Forsblom C, Wu W, Ix JH, Ideker T, Kopp JB, Nigam SK, Cohen CD, Groop PH, Barshop BA, Natarajan L, Nyhan WL, Naviaux RK. 2013 Nov;24(11):1901-12. Epub 2013 Oct 10.
AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, Decleves AE, Andreyev A, Quach T, Ly S, Shekhtman G, Nguyen W, Chepetan A, Le TP, Wang L, Xu M, Paik KP, Fogo A, Viollet B, Murphy A, Brosius F, Naviaux RK, Sharma K. J Clin Invest. 2. 2013 Nov 1;123(11):4888-99. Epub 2013 Oct 25.
Regulation of lipid accumulation by AMK-activated kinase in high fat diet-induced kidney injury. Declèves AE, Zolkipli Z, Satriano J, Wang L, Nakayama T, Rogac M, Le TP, Nortier JL, Farquhar MG, Naviaux RK, Sharma K. 2013 Dec 4. Epub ahead of print.
Adipokines protecting CKD. Miyamoto S, Sharma K. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv15-22.

2012

Visualizing the mouse podocyte with multiphoton microscopy. Khoury CC, Khayat MF, Yeo TK, Pyagay PE, Wang A, Asuncion AM, Sharma K, Yu W, Chen S. 2012 Oct 26;427(3):525-30. Epub 2012 Sep 26.
Sugar, sex, and TGF-β in diabetic nephropathy. Diamond-Stanic MK, You YH, Sharma K. 2012 May;32(3):261-8.
Exp Diabetes Res. 2012;2012:678381. doi: 10.1155/2012/678381. Epub 2012 May 8. Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model. Østergaard JA, Bjerre M, RamachandraRao SP, Sharma K, Nyengaard JR, Hansen TK, Thiel S, Flyvbjerg A. 2012;2012:678381. Epub 2012 May 8.
A role for the organic anion transporter OAT3 in renal creatinine secretion in mice. Vallon V, Eraly SA, Rao SR, Gerasimova M, Rose M, Nagle M, Anzai N, Smith T, Sharma K, Nigam SK, Rieg T. 2012 May 15;302(10):F1293-9. Epub 2012 Feb 15.

2011

Obesity related kidney disease. Mathew AV, Okada S, Sharma K. Curr Diabetes Rev. 2011 Jan 1;7(1):41-9.
Pirfenidone for Diabetic Nephropathy: A Randomized Placebo Controlled Clinical Study. Sharma, K, Ix, J.H., Mathew, A.V., Cho, M, Pflueger, A., Dunn, S.R., Francos, B., Sharma, S, Falkner, B., McGowan, T., Donohue, M., RamachandraRao, S., Xu, R., Fervenza, F., Kopp, J.B. Journal of the American Society of Nephrology 22:1144-1151, 2011
Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes. Maher P, Dargusch R, Ehren JL, Okada S, Sharma K, Schubert D. PLoS One. 2011;6(6):e21226. Epub 2011 Jun 27.
Antifibrotic treatment and other new strategies for improving renal outcomes. Mathew A, Cunard R, Sharma K. Contrib Nephrol. 2011;170:217-27. Epub 2011 Jun 9.
AMPK Mediates the Initiation of High Fat Induced Kidney Disease. Decleves, A-E., Mathew, A.V., Cunard, R., Sharma, K. Journal of the American Society of Nephrology 2011 Oct;22(10):1846-55.
Role of the USF1 Transcription Factor in Diabetic Kidney Disease. Sanchez AP, Zhao J, You YH, Diamond-Stanic M, Sharma K. Am J Physiol Renal Physiol. 2011 Aug;301(2):F271-9. Epub 2011 May 4.
The endoplasmic reticulum stress response and diabetic kidney disease. Cunard R, Sharma K. Am J Physiol Renal Physiol. 2011 May;300(5):F1054-61. Epub 2011 Feb 23.

2010

Mechanisms Linking Obesity, Chronic Kidney Disease, and Fatty Liver Disease: The Roles of Fetuin-A, Adiponectin, and AMPK. Ix JH, Sharma K. J Am Soc Nephrol 2010 Mar;21(3):406-12. Epub 2010 Feb 11.
Sulodexide ameliorates early but not late kidney disease in models of radiation nephropathy and diabetic nephropathy. Rossini M, Naito T, Yang H, Freeman M, Donnert E, Ma LJ, Dunn SR, Sharma K, Fogo AB. Nephrol Dial Transplant. 2010 Jun;25(6):1803-10. Epub 2010 Jan 7.
Regulation of transforming growth factor-beta1 by insulin in prediabetic African Americans. Huan Y, DeLoach S, Daskalakis C, Dunn SR, Sharma K, Falkner B. Kidney Int. 2010 Aug;78(3):318-24. Epub 2010 Apr 14.
TRB3 is stimulated in diabetic kidneys, regulated by the ER Stress marker CHOP and is a suppressor of podocyte MCP-1. Morse E, Schroth J, You YH, Pizzo DP, Okada S, Ramachandrarao SP, Vallon V, Sharma K, Cunard R. Am J Physiol Renal Physiol. 2010 Jul 21. [Epub ahead of print]
The role of aldosteronism in causing obesity-related cardiovascular risk. Calhoun DA, Sharma K. Cardiol Clin. 2010 Aug;28(3):517-27.
Sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Vallon V, Sharma K. Curr Opin Nephrol Hypertens. 2010 Sep;19(5):425-31.
Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes. Satriano J, Mansoury H, Deng A, Sharma K, Vallon V, Blantz RC, Thomson SC. Am J Physiol Cell Physiol. 2010 Aug;299(2):C374-80. Epub 2010 May 26.
New pharmacological treatments for improving renal outcomes in diabetes. Declèves AE, Sharma K. Nat Rev Nephrol. 2010 Jun;6(6):371-80. Epub 2010 May 4.
Role of reactive oxygen species in hyperadrenergic hypertension: biochemical, physiological, and pharmacological evidence from targeted ablation of the chromogranin a (Chga) gene. Gayen JR, Zhang K, RamachandraRao SP, Mahata M, Chen Y, Kim HS, Naviaux RK, Sharma K, Mahata SK, O’Connor DT. Circ Cardiovasc Genet. 2010 Oct 1;3(5):414-25. Epub 2010 Aug 20.
Targeted renal therapies through microbubbles and ultrasound. Deelman LE, Declèves AE, Rychak JJ, Sharma K. Adv Drug Deliv Rev. 2010 Nov 30;62(14):1369-77. Epub 2010 Oct 11.

2009

TGF-ß inhibits Ang II-induced MAPK signaling in vascular smooth muscle cells through downregulation of Ang II type 1 receptors. Meijering, B. Els A. van der Wouden, Vincent Pelgröm, Robert H. Henning, Kumar Sharma, and Leo E. Deelman. Journal of Vascular Research, 10:459-468, 2009
Burnt-out diabetes: impact of chronic kidney disease progression on the natural course of diabetes mellitus. Kalantar-Zadeh K, Derose SF, Nicholas S, Benner D, Sharma K, Kovesdy CP. J Ren Nutr. 2009 Jan;19(1):33-7
Mechanisms of kidney fibrosis and the role of antifibrotic therapies. Deelman L, Sharma K. Curr Opin Nephrol Hypertens. 2009 Jan;18(1):85-90.
Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implications. Bakris GL, Fonseca VA, Sharma K, Wright EM. Kidney Int. 2009 Jun;75(12):1272-7.
Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice. Sanjoy Ghosh, Majid Khazaei, Farzad Moien Afshari, Lisa S. Ang, David J. Granville, Bruce Verchere, Stephen R. Dunn, Peter McCue, Andrew Mizisin, Kumar Sharma, and Ismail Laher. Am J Physiol Renal Physiol 2009 Apr;296(4):F700-8.
Transcription factors in the pathogenesis of diabetic nephropathy. Sanchez AP, Sharma K. Expert Rev Mol Med. 2009 Apr 28;11:e13.
The Link between Obesity and Albuminuria: Adiponectin and Podocyte Dysfunction. Sharma K. Kidney Int. 2009 Jul;76(2):145-8. Epub 2009 Apr 29.
Pirfenidone Is Renoprotective in Diabetic Kidney Disease. Ramachandrarao SP, Zhu Y, Ravasi T, McGowan TA, Toh I, Dunn SR, Okada S, Shaw MA, Sharma K. J Am Soc Nephrol. 2009 Aug;20(8):1765-75. Epub 2009 Jul 2
Mouse Models of Diabetic Nephropathy. Brosius FC 3rd, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, Takahashi N, Takahashi T; for the Animal Models of Diabetic Complications Consortium. J Am Soc Nephrol 2009 Dec;20(12):2503-12.

2008

Adipokines and Albuminuria: A Direct Communication between Adiponectin and Podocytes. Sharma, K. Ramachandra,Rao, S., Qiu, G., Kataoka Usui, H, Zhu, Y., Dunn, S.R., Ouedraogo, R., Hough. K., McCue, P., Chan, L., Falkner, B., Goldstein, B. Journal of Clinical Investigation, 118(5): 1645-1656 (2008). doi:10.1172/JCI32691. The article received an Editorial comment .
Glycemic Control in Diabetic CKD Patients: Where do we Stand? Kovesdy, C., Sharma, K., Kalantar-Zadeh, K. Am J Kidney Dis. 2008 Oct;52(4):766-77.
Uncoupling of ER-Mitochondrial Calcium Communication by Transforming Growth factor-{beta}. Pacher, P., Sharma, K., Csordas G., Zhu, Y., Hajnoczky, G. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1303-12. The article received an Editorial comment .
Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span.3 Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R. Cell Metab. 2008 Jul 2. [Epub ahead of print].