Publications

Management of calciphylaxis in a burn center: A case series and review of the literature.Dado DN , Huang B, Foster DV, Nielsen JS, Gurney JM, Morrow BD, Sharma K, Chung KK, Ainsworth CR. Burns. 2019 Feb;45(1):241-246. PMID: 30322738

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy. Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K. J Mol Cell Cardiol. 2019 Feb;127:232-245. PMID: 30611795

Impaired non-homologous end joining in human primary alveolar type II cells in emphysema. Kosmider B, Lin CR, Vlasenko L, Marchetti N, Bolla S, Criner GJ, Messier E, Reisdorph N, Powell RL, Madesh M, Kelsen S, Xander N, Correll KA, Mason RJ, Bahmed K. Sci Rep. 2019 Jan 29;9(1):920. PMID: 30696938

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury. Woods JJ, Nemani N, Shanmughapriya S, Kumar A, Zhang M, Nathan SR, Thomas M, Carvalho E, Ramachandran K, Srikantan S, Stathopulos PB, Wilson JJ, Madesh M. ACS Cent Sci. 2019 Jan 23;5(1):153-166. PMID: 30693334

Myofibroblasts acquire retinoic acid-producing ability during fibroblast-to-myofibroblast transition following kidney injury. Nakamura J, Sato Y, Kitai Y, Wajima S, Yamamoto S, Oguchi A, Yamada R, Kaneko K, Kondo M, Uchino E, Tsuchida J, Hirano K, Sharma K, Kohno K, Yanagita M. Kidney Int. 2019 Jan 16. pii: S0085-2538(18)30806-8. PMID: 30661714

Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. J Cell Physiol. 2019 Jan 13. PMID: 30637731

Sex-Related Disparities in CKD Progression. Ricardo AC, Yang W, Sha D, Appel LJ, Chen J, Krousel-Wood M, Manoharan A, Steigerwalt S, Wright J, Rahman M, Rosas SE, Saunders M, Sharma K, Daviglus ML, Lash JP; CRIC Investigators. J Am Soc Nephrol. 2019 Jan;30(1):137-146. PMID: 30510134

Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial. de Zeeuw D, Renfurm RW, Bakris G, Rossing P, Perkovic V, Hou FF, Nangaku M, Sharma K, Heerspink HJL, Garcia-Hernandez A, Larsson TE. Lancet Diabetes Endocrinol. 2018 Dec;6(12):925-933. PMID: 30413396

Self-reported Intentional Weight Loss and Risk of Death in Moderate Chronic Kidney Disease in the United States.  Bansal S, Wei G, Boucher RE, Beddhu S.  J Ren Nutr. 2018 Nov;28(6):422-427. PMID: 30077396

Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. Myers VD, Gerhard GS, McNamara DM, Tomar D, Madesh M, Kaniper S, Ramsey FV, Fisher SG, Ingersoll RG, Kasch-Semenza L, Wang J, Hanley-Yanez K, Lemster B, Schwisow JA, Ambardekar AV, Degann SH, Bristow MR, Sheppard R, Alexis JD, Tilley DG, Kontos CD, McClung JM, Taylor AL, Yancy CW, Khalili K, Seidman JG, Seidman CE, McTiernan CF, Cheung JY, Feldman AM. JAMA Cardiol. 2018 Oct 1;3(10):929-938. PMID: 30140897

The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation. Hirschler-Laszkiewicz I, Chen SJ, Bao L, Wang J, Zhang XQ, Shanmughapriya S, Keefer K, Madesh M, Cheung JY, Miller BA. Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C571-C586. PMID: 30020827

Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction. Cheung JY, Wang J, Zhang XQ, Song J, Davidyock JM, Prado FJ, Shanmughapriya S, Worth AM, Madesh M, Judenherc-Haouzi A, Haouzi P. Cardiovasc Toxicol. 2018 Oct;18(5):407-419. PMID: 29603116

Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. Myers VD, Tomar D, Madesh M, Wang J, Song J, Zhang XQ, Gupta MK, Tahrir FG, Gordon J, McClung JM, Kontos CD, Khalili K, Cheung JY, Feldman AM. J Cell Physiol. 2018 Sep; 233(9):6319-6326. PMID: 29323723

Molecular regulation of MCU: Implications in physiology and disease. Nemani N, Shanmughapriya S, Madesh M. Cell Calcium. 2018 Sep; 74:86-93. Review. PMID: 29980025

A new drug combination significantly reduces kidney tumor progression in kidney mouse model. Liang S, Cuellar T, Nowacki M, Nayak BK, Dong L, Li B, Sharma K, Habib SL. Oncotarget. 2018 Aug 31;9(68):3PMID: 30250638 2900-32916.

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation. Shanmughapriya S, Tomar D, Dong Z, Slovik KJ, Nemani N, Natarajaseenivasan K, Carvalho E, Lu C, Corrigan K, Garikipati VNS, Ibetti J, Rajan S, Barrero C, Chuprun K, Kishore R, Merali S, Tian Y, Yang W, Madesh M. Nat Commun. 2018 Aug 29;9(1):3449. PMID: 30158529

Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease. Afshinnia F, Zeng L, Byun J, Wernisch S, Deo R, Chen J, Hamm L, Miller ER, Rhee EP, Fischer MJ, Sharma K, Feldman HI, Michailidis G, Pennathur S; CRIC Study Investigators. Nephrol Dial Transplant. 2018 Jul 25. PMID: 30137494

Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies. Sharma K, Paša-Tolić L. Kidney Int. 2018 Jun;93(6):1265-1267. PMID: 29792268

The Warburg Effect in Diabetic Kidney Disease. Zhang G, Darshi M, Sharma K. Semin Nephrol. 2018 Mar;38(2):111-120. PMID: 29602394.

Introduction: Systems Biology of Kidney Disease. Sharma K, Susztak K, Pennathur S. Semin Nephrol. 2018 Mar;38(2):99-100.  PMID: 29602402.

Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus. Yamamoto CM, Murakami T, Oakes ML, Mitsuhashi M, Kelly C, Henry RR, Sharma K. Am J Nephrol. 2018 May 18;47(5):283-291. PMID: 29779026.

Urine Metabolites are associated with glomerular lesions in type 2 diabetes.  Saulnier P-J, Darshi M, Wheelock KM, Looker HC, Fufaa, GD, Knowler WC, Weil EJ, Tanamas SK, Lemley KV, Saito R, Natarajan L, Nelson RG, and Sharma K.  Metabolomics. 2018 14:84.

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Conference Presentations

UT Health Division of Nephrology Poster/Oral Presentations at ASN – October 23-28, 2018

Thursday, October 25, 2018

Shweta Bansal, M.D.
Abstract No: 3012137Title: “Chronic kidney diseases (CKD) screening rate and blood pressure (BP) control in Veterans with hypertension”
Poster Session:
Session Title: Hypertension and CVD: Epidemiology, Risk Factors, Prevention [PO1401-1]
Session Date, Time: October 25, 2018 from 10:00 AM to 12:00 PM
Poster Board #: TH-PO442

Manoj Bhattarai
Abstract No: TH-PO882
Title: “Pirfenidone May Protect Against Diabetic Kidney Disease by Reducing Fumarate”
Session Information:
Diabetic Kidney Disease: Basic – I
October 25, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM – 10:00 AM

Brittaini Bunce
Abstract No: 3013863
Title: “Breaking the Rules on PTLD”
Poster Session:
Session Title: Trainee Case Reports – II [PO2000-4]
Session Date, Time: October 25, 2018 from 10:00 AM to 12:00 PM
Poster Board #: TH-PO574

Jiwan John Kim
Abstract No: 3022761
Title: “Pirfenidone may protect against diabetic kidney disease by reducing fumarate”
Poster Session:
Session Title: Diabetic Kidney Disease: Basic – I [PO0601-1]
Session Date, Time: October 25, 2018 from 10:00 AM to 12:00 PM
Poster Board #: TH-PO882 

Debnath Subrata
Abstract No: 3024320
Title: “Fatigue on Hemodialysis Day is Associated with Post-hemodialysis Amino Acids Depletion
Poster Session:
Session Title: Dialysis: Cost, Socioeconomics, Quality of Life [PO0701-1]
Session Date, Time: October 25, 2018 from 10:00 AM to 12:00 PM
Poster Board #: TH-PO312 

Guanshi Zhang
Abstract No: 3024773
Title: “MALDI-MSI and METASPACE annotation of normal human renal cortical tissue reveals consistent lipid remodeling”
Poster Session:
Session Title: Diabetic Kidney Disease: Basic – I [PO0601-1]
Session Date, Time: October 25, 2018 from 10:00 AM to 12:00 PM
Poster Board #: TH-PO871 

Soumya Maity, Ph.D.
Poster 1:
Abstract No: 3016710
Title: “PI 3 kinase/Akt node acts as a driver for high glucose-induced miR-214 expression to induce a positive feedback loop via PTEN for matrix protein expression in proximal tubular epithelial cells (PTECs)”​
Poster Session:
Session Title: Diabetic Kidney Disease: Basic – I [PO0601-1]
Session Date, Time: October 25, 2018 from 10:00 AM to 12:00 PM
Poster Board #: TH-PO884

Friday, October 26, 2018

Soumya Maity, Ph.D.
Poster 2:

Abstract No:​ 3015241
Title: “A cross-talk between TGFbeta receptor (TGFbR) and PDGF receptor-beta (PDGFRb) controls mTORC1-mediated mesangial cell (MC) hypertrophy and fibrotic protein expression”​
Poster Session:
Session Title: Diabetic Kidney Disease: Basic – II [PO0601-2]
Session Date, Time: October 26, 2018 from 10:00 AM to 12:00 PM
Poster Board #: FR-PO380​ 

Ricardo Rodriguez-Santos, M.D.
Abstract No: 3024637
Title: “Spontaneous rupture of peritoneal dialysis catheter with no drainage problem”
Poster Session:
Session Title: Trainee Case Reports – IV [PO2000-5]
Session Date, Time: October 26, 2018 from 10:00 AM to 12:00 PM
Poster Board #: FR-PO1095 

Falguni Das, Ph.D.
Abstract No:  3016040
Title: “Deacetylation of S6 kinase (S6K) by high glucose drives mesangial cell (MC) hypertrophy and matrix expansion in diabetic nephropathy (DN)”
Poster Session:
Session Title: Diabetic Kidney Disease: Basic – II [PO0601-2]
Session Date, Time: October 26, 2018 from 10:00 AM to 12:00 PM
Poster Board #: FR-PO393 

Manjula Darshi, Ph.D.
Abstract No: 3022591
Title: “Urine Metabolites Predict Kidney Function Decline in Type I Diabetic Subjects”
Poster Session:
Session Title: Diabetic Kidney Disease: Clinical – I [PO0602-1]
Session Date, Time: October 26, 2018 from 10:00 AM to 12:00 PM
Your Poster Board #: FR-PO382 

Saturday, October 27, 2018

Kumar Sharma, M.D. (Speaker at Educational Symposium)
Session Title: Reshaping Our Approach to CKD
Lecture Title: Inflammatory Pathways in CKD Progression
Time: 12:45 – 1:45 p.m.
Location: San Diego Convention Center, North Tower Grand Ballroom, Salon 5, 11 W. Harbor Dr., San Diego, CA 92101
For More information

Andrew Donati
Title: “Chloride channel accessory protein could be a novel regulatory factor in aging related changes in the kidney”
Session Title: Geriatric Nephrology [PO1100-1]
Session Date, Time: October 27, 2018 from 10:00 AM to 12:00 PM
Poster Board #: SA-PO729 

Hak Joo Lee, Ph.D.
Title: “Marmoset – a non-human primate model to study aging associated changes in the kidney”
Session Title: Geriatric Nephrology [PO1100-1]
Session Date, Time: October 27, 2018 from 10:00 AM to 12:00 PM
Poster Board #: SA-PO731 

Kai Chin, M.D.
Title: “Baroreceptor Failure – A Rare Form of Secondary Hypertension”
Poster Session:
Session Title: Trainee Case Reports – VI [PO2000-6]
Session Date, Time: October 27, 2018 from 10:00 AM to 12:00 PM
Poster Board #: SA-PO299

Abstract No: SA-PO223
Title: “Myeloma-Like Cast Nephropathy in a Patient with Pancreatic Mixed Acinar-Neuroendocrine Cancer”
Session Information:
Trainee Case Reports – V
October 27, 2018 | Location: Exhibit Hall, San Diego Convention Center
Abstract Time: 10:00 AM – 10:00 AM

Shweta Bansal, M.D.
Abstract No: 3012118
Title: “Safety and efficacy of high dose spironolactone in loop diuretic resistant acute decompensated heart failure”
Oral Abstract Session
Session Title: Hypertension and CVD: Epidemiology and Outcomes [OR1401-1]
Session Date, Time: October 27, 2018 from 4:30 PM to 6:30 PM
Session Room: 6F (San Diego Convention Center)
Abstract Publication #: SA-OR055
Presentation Time: 5:54 PM to 6:06 PM

ASN Kidney Week Conference 2014

  • Mitochondria and Metabolomics in Diabetic Complications
    Time: 3:12pm – 3:36pm
    Speaker: Kumar Sharma
  • Session – Role of Reactive Oxygen Species in Diabetic Nephropathy
    Type: Basic and Clinical Science Symposium
    Date: Sunday, November 16, 2014
    Time: 10:00am – 12:00pm
    Moderator: Kumar Sharma
  • Restoring Mitochondrial Superoxide Levels with BendaviaTM Protects Against Progression of Diabetic Kidney Disease in db/db Mice
    Speaker: Satoshi Miyamoto
    Satoshi Miyamoto, Manjula Darshi, Larkin B. Slater, Tai Nguyen, Peter J. Oates and Kumar Sharma. Center for Renal Translational Medicine, University of California, San Diego, La Jolla, CA, United States; Veterans Administration San Diego HealthCare System, La Jolla, CA, United States and Stealth Peptides, Inc., Newton, MA, United States.
  • Cholecystokinin Activates AMPK and Protects Against Progression of Diabetic Kidney Disease in db/db Mice
    Speaker: Satoshi Miyamoto
    Satoshi Miyamoto, Maggie K. Diamond-stanic, Manjula Darshi1, Tammy Quach1, Larkin B. Slater, and Kumar Sharma. Center for Renal Translational Medicine, University of California, San Diego, La Jolla, CA, United States and Veterans Administration San Diego HealthCare System, La Jolla, CA, United States.
  • High Spatial and Spectral Resolution Mass Spectrometry Imaging Reveals Reduced AMP and Elevated ATP Levels in Glomeruli of Diabetic Mice
    Speaker: Satoshi Miyamoto
    Satoshi Miyamoto, Gregory Hamm, Jonathan Stauber, Pieter Dorrestein, and Kumar Sharma. Institute of Metabolomic Medicine, University of California, San Diego, La Jolla, CA, United States; Center for Renal Translational Medicine, University of California, San Diego, La Jolla, CA, United States; Veterans Affairs San Diego Healthcare System, La Jolla, CA, United States; MS Imaging Department, ImaBiotech, Lille, France and Therapeutic Discovery Mass Spectrometry Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States.